Mixed polysaccharides derived from shiitake mushroom, Poriacocos, Ginger, and Tangerine peel prevent the H1N1 virus infections in mice
Mixed polysaccharides derived from shiitake mushroom, Poriacocos, Ginger, and Tangerine peel prevent the H1N1 virus infections in mice
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香菇、茯苓、生姜和陈皮中提取的混合多糖可预防小鼠 H1N1 病毒感染
DOI：
10.1093/bbb/zbab174
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发表时间：
2021-10-08
影响因子：
1.6
通讯作者：
Han，Li
中科院分区：
文献类型：
--
作者：
Yang，Diqi;Hu，Minghua;Han，Li
大流行甲型H1N1流感病毒在全球蔓延，构成最严重的全球公共卫生挑战之一。中药与疫苗免疫作为补充治疗策略。在这里，我们证明了源自香菇、茯苓、生姜和柑橘皮的混合多糖（MP）可以预防小鼠的 H1N1 病毒感染。 MP 预处理可减轻 H1N1 病毒引起的体重减轻、临床症状和死亡。淋巴细胞检测结果显示，MP预处理后胸腺中CD3+、CD19+、CD25+细胞比例上调。此外，MP预处理减少了肺内炎症细胞浸润，增加了CD19+、CD25+和CD278+细胞比例。然而，MP治疗对H1N1病毒攻击后没有有效的治疗作用。目前的研究表明，MP 预处理可以减轻 H1N1 病毒引起的肺损伤，并上调未免疫小鼠的体液和细胞免疫反应。
The pandemic influenza A (H1N1) virus spread globally and posed one of the most serious global public health challenges. The traditional Chinese medicine is served as a complementary treatment strategy with vaccine immunization. Here, we demonstrated that the mixed polysaccharides (MPs) derived from shiitake mushroom, poriacocos, ginger, and tyangerine peel prevent the H1N1 virus infections in mice. MP pretreatment attenuated H1N1 virus-induced weight loss, clinical symptoms, and death. The lymphocytes detection results showed that the CD3+, CD19+, and CD25+cell proportions were upregulated in thymus under MP pretreatment. Besides, MP pretreatment reduced the inflammatory cell infiltration and increased the cell proportions of CD19+, CD25+, and CD278+in lung. However, MP treatment have no effective therapeutic effect after H1N1 virus challenge. The current study suggested that pretreatment with MPs could attenuate H1N1 virus-induced lung injury and upregulate humoral and cellular immune responses in nonimmunized mice.