Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections
Syphilis increases HIV viral load and decreases CD4 cell counts in HIV-infected patients with new syphilis infections
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DOI：
10.1097/00002030-200410210-00012
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发表时间：
2004-10-21
期刊：
影响因子：
3.8
通讯作者：
Klausner, JD
中科院分区：
文献类型：
--
作者：
Buchacz, K;Patel, P;Klausner, JD
背景资料：梅毒溃疡是已知的，以促进艾滋病毒感染的传播，但梅毒感染对艾滋病毒载量和CD 4细胞计数的影响知之甚少understood.Methods：我们抽象的医疗记录艾滋病毒感染的男性梅毒患者在三个诊所在旧金山弗朗西斯科和洛杉矶从2001年1月至2003年4月。我们比较了血浆HIV-RNA水平和CD 4细胞计数在梅毒感染与梅毒感染前和梅毒治疗后，使用Wilcoxon签署的秩检验。结果：52名HIV感染的男性与一期或二期梅毒的HIV病毒载量和CD 4细胞计数数据可供分析; 30（58%）正在接受抗逆转录病毒治疗。与梅毒前水平相比，梅毒期间的病毒载量平均高出0.22 RNA log（10）拷贝/ml（P = 0.02），梅毒治疗后平均低出-0.10 RNA log（10）拷贝/ml（P = 0.52）。CD 4细胞计数在梅毒感染期间比感染前平均降低了-62个/mm（3）（P = 0.04），在梅毒治疗后平均升高了33个/mm（3）（P = 0.23）。在HIV病毒载量和CD 4细胞计数减少的增加是最大的男性与二期梅毒和那些没有接受抗逆转录病毒therapy.Conclusion：梅毒感染与HIV病毒载量的显着增加和CD 4细胞计数显着下降。这些发现强调了预防和及时治疗艾滋病毒感染者梅毒的重要性。(C)2004年利平科特威廉姆斯威尔金斯。
Background: Syphilitic ulcers are known to facilitate the transmission of HIV infection, but the effect of syphilis infection on HIV viral loads and CD4 cell counts is poorly understood.Methods: We abstracted medical records for HIV-infected male syphilis patients seen at three clinics in San Francisco and Los Angeles from January 2001 to April 2003. We compared plasma HIV-RNA levels and CD4 cell counts during syphilis infection with those before syphilis infection and after syphilis treatment, using the Wilcoxon signed rank test.Results: Fifty-two HIV-infected men with primary or secondary syphilis had HIV viral load and CD4 cell count data available for analysis; 30 (58%) were receiving antiretroviral therapy. Viral loads were higher during syphilis compared with presyphilis levels by a mean of 0.22 RNA loglo copies/ml (P = 0.02) and were lower by a mean of -0.10 RNA log(10) copies/ml (P = 0.52) after syphilis treatment. CD4 cell counts were lower during syphilis infection than before by a mean of -62 cells/mm(3) (P = 0.04), and were higher by a mean of 33 cells/mm(3) (P = 0.23) after syphilis treatment. Increases in the HIV viral load and reductions in the CD4 cell count were most substantial in men with secondary syphilis and those not receiving antiretroviral therapy.Conclusion: Syphilis infection was associated with significant increases in the HIV viral load and significant decreases in the CD4 cell count. The findings underscore the importance of preventing and promptly treating syphilis in HIV-infected individuals. (C) 2004 Lippincott Williams Wilkins.