LTP of GABAergic synapses in the ventral tegmental area and beyond
LTP of GABAergic synapses in the ventral tegmental area and beyond
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DOI：
10.1113/jphysiol.2007.148098
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发表时间：
2008-03-15
影响因子：
5.5
通讯作者：
Kauer, Julie A.
中科院分区：
文献类型：
--
作者：
Nugent, Fereshteh S.;Kauer, Julie A.
神经回路的经验依赖性重组的机制之一是通过突触强度的变化。哺乳动物大脑中几乎每一个兴奋性突触都表现出LTP（长时程增强）或LTD（长时程抑制），这是突触可塑性的两种细胞机制。然而，LTP和LTD在快速抑制性GABA（A）受体突触中的报道要少得多。我们最近的研究表明，在体内吗啡启动一个持久的改变GABA能突触腹侧被盖区（VTA）通过阻断GABA能突触的LTP所需的机制。在这里，我们把这项工作的背景下，其他例子的突触可塑性在GABA能突触。
One of the mechanisms by which the experience-dependent reorganization of neural circuitry can occur is through changes in synaptic strength. Almost every excitatory synapse in the mammalian brain exhibits LTP (long-term potentiation) or LTD (long-term depression), two cellular mechanisms of synaptic plasticity. However, LTP and LTD have been reported much more rarely at fast inhibitory GABA(A) receptor synapses. Our recent study suggests that in vivo morphine initiates a long-lasting alteration of GABAergic synapses in the ventral tegmental area (VTA) by blocking the mechanisms required for LTP of GABAergic synapses. Here we put this work into the context of other examples of synaptic plasticity at GABAergic synapses.