α1-Adrenergic Receptors Contribute to the Acute Effects of 3,4-Methylenedioxymethamphetamine in Humans
α1-Adrenergic Receptors Contribute to the Acute Effects of 3,4-Methylenedioxymethamphetamine in Humans
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DOI：
10.1097/jcp.0b013e3182979d32
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发表时间：
2013-10-01
影响因子：
2.9
通讯作者：
Liechti, Matthias E.
中科院分区：
文献类型：
--
作者：
Hysek, Cedric M.;Fink, Anja E.;Liechti, Matthias E.
临床前研究表明，α(1)-去甲肾上腺素能受体在精神刺激剂的作用中起作用，包括3，4-亚甲基二氧基甲基苯丙胺(MDMA，“摇头丸”)。本研究评价了α(1)-去甲肾上腺素受体拮抗剂多沙唑嗪对16名健康受试者MDMA急性药效学和药代动力学反应的影响。采用随机、双盲、安慰剂对照、4个疗程的交叉设计，在服用MDMA(125 Mg)或安慰剂之前，给予多沙唑嗪(8 mg/d)或安慰剂3天。多沙唑嗪降低了MDMA引起的血压和体温升高，并适度减弱了积极情绪，但增加了与MDMA相关的心动过速。结果表明，α(1)-肾上腺素能受体参与了急性心脏刺激剂的作用，并在很小程度上可能也参与了MDMA对人体的发热和兴奋作用。
Preclinical studies implicate a role for alpha(1)-noradrenergic receptors in the effects of psychostimulants, including 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy''). The present study evaluated the effects of the alpha(1)-noradrenergic receptor antagonist doxazosin on the acute pharmacodynamic and pharmacokinetic response toMDMA in 16 healthy subjects. Doxazosin (8 mg/d) or placebo was administered for 3 days before MDMA (125 mg) or placebo using a randomized, double-blind, placebo-controlled, 4-session, crossover design. Doxazosin reduced MDMA-induced elevations in blood pressure, body temperature, and moderately attenuated positive mood but enhanced tachycardia associated with MDMA. The results indicate that alpha(1)-adrenergic receptors contribute to the acute cardiostimulant and to a minor extent possibly also to the thermogenic and euphoric effects of MDMA in humans.