Protein tyrosine phosphatase PTPN2 regulates TGF-β signaling through Smad4 dephosphorylation.
Protein tyrosine phosphatase PTPN2 regulates TGF-β signaling through Smad4 dephosphorylation.
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蛋白酪氨酸磷酸酶 PTPN2 通过 Smad4 去磷酸化调节 TGF-β 信号传导。
DOI:
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发表时间:
2022
期刊:
影响因子:
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通讯作者:
Xin-Hua Feng
中科院分区:
文献类型:
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作者:
Sujing Shi;Dewei Xu;Shuchen Gu;Ningyi Xu;Pinglong Xu;Jin Cao;Xin-Hua Feng
Transforming Growth Factor beta (TGF-β) is a multifunctional cytokine that regulates cell proliferation, differentiation, and apoptosis. Dysregulation of the TGF-β signaling is one of the major mechanisms underlying tumor progression. We have previously r