Risk factors and biofilm formation analyses of hospital-acquired infection of Candida pelliculosa in a neonatal intensive care unit.
Risk factors and biofilm formation analyses of hospital-acquired infection of Candida pelliculosa in a neonatal intensive care unit.
复制标题
新生儿重症监护病房医院获得性薄壁念珠菌感染的危险因素及生物膜形成分析
DOI：
10.1186/s12879-021-06295-1
复制
发表时间：
2021-06-29
影响因子：
3.7
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Zhang Z;Cao Y;Li Y;Chen X;Ding C;Liu Y
研究背景透明念珠菌是一种能引起免疫功能低下个体感染的生态真菌。全球范围内的大量研究表明，C.新生儿会感染薄膜菌。爆发最近发生在我们的新生儿重症监护病房，因此，我们的目的是评估在这家医院获得性真菌感染的危险因素。MethodsWe进行了病例对照研究，分析新生儿感染的潜在危险因素ofC。因此，我们认为感染预防和控制可以在我们的单位实施。分离菌株进行了测试耐药性和生物膜形成，真菌传播的重要因素，引起医院获得性infections.ResultsThe使用三种或更多种广谱抗菌药物或长期住院与较高的感染可能性与C。具表膜的。在医护人员的手上或环境中没有发现这种真菌。所有真菌分离株对抗真菌药物敏感，抗真菌治疗后，所有感染患者均恢复。严格的感染预防和控制程序有效地抑制了感染传播。完整的粘附素编码基因，基因组分析表明，真菌transmiss.ConclusionsThe使用三个或更多的广谱抗菌药物或住院时间长，理论上与感染的风险与C。具表膜的。我们分离出的菌株对抗真菌药物敏感，通过对所有患者进行抗真菌治疗，这些菌株都被消除了。传播可能是通过粘附到细胞表面和生物膜形成。
BackgroundCandida pelliculosais an ecological fungal species that can cause infections in immunocompromised individuals. Numerous studies globally have shown thatC. pelliculosainfects neonates. An outbreak recently occurred in our neonatal intensive care unit; therefore, we aimed to evaluate the risk factors in this hospital-acquired fungal infection.MethodsWe performed a case-control study, analysing the potential risk factors for neonatal infections ofC. pelliculosaso that infection prevention and control could be implemented in our units. Isolated strains were tested for drug resistance and biofilm formation, important factors for fungal transmission that give rise to hospital-acquired infections.ResultsThe use of three or more broad-spectrum antimicrobials or long hospital stays were associated with higher likelihoods of infection withC. pelliculosa. The fungus was not identified on the hands of healthcare workers or in the environment. All fungal isolates were susceptible to anti-fungal medications, and after anti-fungal treatment, all infected patients recovered. Strict infection prevention and control procedures efficiently suppressed infection transmission. Intact adhesin-encoding genes, shown by genome analysis, indicated possible routes for fungal transmission.ConclusionsThe use of three or more broad-spectrum antimicrobials or a lengthy hospital stay is theoretically associated with the risk of infection withC. pelliculosa. Strains that we isolated are susceptible to anti-fungal medications, and these were eliminated by treating all patients with an antifungal. Transmission is likely via adhesion to the cell surface and biofilm formation.