Highly Fluorescent Polycaprolactones with Tunable Light Emission Wavelengths across Visible to NIR Spectral Window
Highly Fluorescent Polycaprolactones with Tunable Light Emission Wavelengths across Visible to NIR Spectral Window
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DOI：
10.1002/admi.201600259
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发表时间：
2016-09-06
影响因子：
5.4
通讯作者：
Wang, Mingfeng
中科院分区：
文献类型：
--
作者：
Huang, Shuo;Wang, Kai;Wang, Mingfeng
聚己内酯（PCL）具有良好的生物降解性、生物相容性和机械加工性，已广泛应用于生物医学领域，如组织工程。然而，市售的PCL没有任何荧光不能满足生物医学应用中日益增长的需求，例如，在组织工程中非侵入性地监测植入支架的命运。为此，探索新的荧光PCL聚合物在跟踪其在生理条件下的降解和区分PCL支架与生物系统（如细胞和组织）的界面上起着至关重要的作用。在此，本研究报告了一系列量身定制的荧光PCL聚合物与各种发光波长范围从可见光到近红外（NIR）区域的固态。这些荧光PCL聚合物适合于使用静电纺丝加工成纳米纤维，以及用于宏观冲压、毛笔书写和微接触印刷的水性纳米颗粒油墨。最后，应用近红外荧光PCL在体外成像和监测支架降解的证明。
Polycaprolactone (PCL) has been widely used in biomedical applications such as tissue engineering due to its promising biodegradability, biocompatibility, and mechanical processability. However, commercially available PCL without any fluorescence does not meet the increasing demand in biomedical applications, for example, to monitor noninvasively the fate of implanted scaffolds in tissue engineering. To that end, exploration of new fluorescent PCL polymers plays an essential role in tracking their degradation under physiological conditions and distinguishing PCL scaffolds at the interface with biological systems such as cells and tissues. Herein, this study reports a series of tailor-made fluorescent PCL polymers with various light emission wavelengths ranging from visible to near-infrared (NIR) region in solid states. These fluorescent PCL polymers are amenable to be processed into nanofibers using electrospinning, as well as waterborne nanoparticle ink for macroscale stamping, brush writing, and microcontact printing. Finally, the application of the NIR fluorescent PCL for in vitro imaging and monitoring of scaffold degradation is demonstrated.