Regulation of membrane trafficking in polarized epithelial cells
Regulation of membrane trafficking in polarized epithelial cells
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DOI：
10.1016/j.ceb.2008.01.003
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发表时间：
2008-04-01
影响因子：
7.5
通讯作者：
Folsch, Heike
中科院分区：
文献类型：
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作者：
Folsch, Heike
极化的上皮细胞不断地将跨膜蛋白分选到顶端或基底侧的质膜域。近年来的研究在了解通往基底区或顶区的主要途径的分子机制方面取得了巨大的进展。这一理解将有助于我们阐明这些通路是如何相互连接的，以确保维持细胞的极性和上皮单层的完整性。
Polarized epithelial cells continuously sort transmembrane proteins to either apical or basolateral plasma membrane domains. Research in recent years has made tremendous progress in understanding the molecular mechanisms of the major pathways to either basolateral or apical domain. This understanding will help us elucidating how these pathways are interconnected in ensuring maintenance of cell polarity and integrity of epithelial monolayers.