Optical coherence tomography angiography and photoacoustic imaging in dermatology
Optical coherence tomography angiography and photoacoustic imaging in dermatology
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DOI：
10.1039/c8pp00471d
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发表时间：
2019-05-01
影响因子：
3.1
通讯作者：
Drexler, Wolfgang
中科院分区：
文献类型：
--
作者：
Liu, Mengyang;Drexler, Wolfgang
光学相干断层扫描血管造影（OCTA）是一种相对新颖的功能扩展，广泛接受的眼科成像工具，称为光学相干断层扫描（OCT）。自从OCTA在眼科首次亮相以来，研究人员也一直在努力扩大其在皮肤科的转化应用。OCTA分辨微血管的能力在皮肤疾病成像中显示出有希望的结果。同时，利用激光脉冲诱导的超声波作为信号的光声成像（派）已经被研究用于区分人类皮肤层并帮助皮肤疾病诊断。本文就OCTA和派在光皮肤病学领域的应用作一简要综述。在介绍了OCTA和派的原理后，我们描述了使用这两种光学成像模式进行皮肤疾病成像的最新结果。我们还强调双模态成像结合OCTA和光声断层扫描（PAT）的皮肤病学应用。最后，讨论了这两种成像方式在皮肤病学中的挑战和前景。
Optical coherence tomography angiography (OCTA) is a relatively novel functional extension of the widely accepted ophthalmic imaging tool named optical coherence tomography (OCT). Since OCTA's debut in ophthalmology, researchers have also been trying to expand its translational application in dermatology. The ability of OCTA to resolve microvasculature has shown promising results in imaging skin diseases. Meanwhile, photoacoustic imaging (PAI), which uses laser pulse induced ultrasound waves as the signal, has been studied to differentiate human skin layers and to help in skin disease diagnosis. This perspective article gives a short review of OCTA and PAI in the field of photodermatology. After an introduction to the principles of OCTA and PAI, we describe the most updated results of skin disease imaging using these two optical imaging modalities. We also place emphasis on dual modality imaging combining OCTA and photoacoustic tomography (PAT) for dermatological applications. In the end, the challenges and prospects of these two imaging modalities in dermatology are discussed.