Ultraviolet Photofunctionalization of Titanium Implants
Ultraviolet Photofunctionalization of Titanium Implants
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DOI：
10.11607/jomi.te47
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发表时间：
2014-01-01
影响因子：
2
通讯作者：
Ogawa, Takahiro
中科院分区：
文献类型：
--
作者：
Ogawa, Takahiro
面对种植体治疗日益增长的需求和挑战，需要具有改善的生物性能的种植体表面。本文综述了近年来钛的紫外光功能化在体外和体内的研究结果。紫外光功能化是指钛表面经紫外光处理后发生的物理化学性质的改变和生物学性能的增强的综合现象。与未经处理的对照种植体相比，经UV处理的钛种植体周围的骨形态发生明显改善，导致在动物模型中骨与种植体接触接近100%的骨整合快速而完整地建立，而未经处理的种植体的骨整合率低于55%。一系列体外研究表明，紫外线处理后，动物和人类的成骨细胞的附着、保留和随后的功能级联反应显著增强。紫外线处理将钛表面从疏水性转化为超亲水性，并去除可降解的污染碳氢化合物。紫外线处理的钛表面还表现出独特的静电状态，并在没有离子和有机桥的帮助下作为直接的细胞吸引剂，这赋予了钛一种新的物理化学功能，长期以来一直被认为是一种生物惰性材料。UV处理简单且成本低，已被证明对所有类型的钛表面都有效。这些数据表明，紫外线光功能化可以是一种新的，有效的措施，以提高种植体治疗在牙科和骨科领域。未来的研究将集中在临床研究中验证这些发现。
In the face of growing demands and challenges in implant therapy, implant surfaces with improved biologic capabilities are required. This review paper summarizes the findings of recent in vitro and in vivo studies related to ultraviolet (UV) photofunctionalization of titanium. UV photofunctionalization is defined as an overall phenomenon of modification of titanium surfaces occuring after UV treatment, including the alteration of physicochemical properties and the enhancement of biologic capabilities. Bone morphogenesis around UV-treated titanium implants is distinctly improved compared with that seen around untreated control implants, leading to rapid and complete establishment of osseointegration with nearly 100% bone-to-implant contact in an animal model, as opposed to less than 55% for untreated implants. A series of in vitro studies demonstrated considerable enhancement of attachment, retention, and subsequent functional cascades of osteogenic cells derived from animals and humans after UV treatment. UV treatment converts titanium surfaces from hydrophobic to superhydrophilic and removes unavoidably contaminated hydrocarbons. UV-treated titanium surfaces also manifest a unique electrostatic status and act as direct cell attractants without the aid of ionic and organic bridges, which imparts a novel physicochemical functionality to titanium, which has long been understood as a bioinert material. UV treatment is simple and low in cost, and it has been proven effective for all types of titanium surfaces tested. These data suggest that UV photofunctionalization can be a novel, effective measure to improve implant therapy in the dental and orthopedic fields. Future research will focus on validating these findings in clinical studies.