Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study
Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study
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DOI：
10.1093/ajcn/80.4.862
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发表时间：
2004-10-01
影响因子：
7.1
通讯作者：
Stefanadis, C
中科院分区：
文献类型：
--
作者：
Zampelas, A;Panagiotakos, DB;Stefanadis, C
背景：饮用咖啡对心血管系统的影响是相互矛盾的。炎症对心血管疾病（CVD）的发展很重要，一些饮食因素被认为对炎症产生显著影响，从而对CVD的风险产生显著影响。目的：我们旨在研究咖啡消费和炎症标志物之间的关联。设计：横断面调查纳入了1514名男性（（x）超过标准差，年龄：46 +/- 13岁;范围：18-87岁）和1528名女性（年龄45 +/- 13岁;范围：18-89岁）。5%的男性和3%的女性被排除在CVD病史之外。采集空腹血样。饮食习惯（包括消费各种类型的咖啡）进行了评估，通过使用验证的食物频率问卷。结果：与不喝咖啡的人相比，每天喝200毫升咖啡的人白细胞介素6（IL-6）高50%，C反应蛋白（CRP）高30%，血清淀粉样蛋白A（SAA）高12%，肿瘤坏死因子α（TNF-α）浓度升高28%，白色细胞（WBC）计数升高3%（均P < 0.05）。与不喝咖啡的女性相比，每天喝咖啡超过200 mL的女性IL-6、CRP、SAA、TNF-α浓度和WBC计数分别高出54%、38%、28%和28%以及4%（P < 0.05）。研究结果是显着的，即使控制后的咖啡消费量和年龄，性别，吸烟，体重指数，体力活动状态，和其他covariatings.Conclusions之间的相互作用：中到高的咖啡消费量和炎症过程增加之间存在的关系。这种关系可以部分解释咖啡摄入量增加对心血管系统的影响。
Background: The effect of coffee consumption on the cardiovascular system is conflicting. Inflammation is important to the development of cardiovascular disease (CVD), and several dietary factors are thought to exert significant effects on inflammation and thus on the risk of CVD.Objective: We aimed to investigate the associations between coffee consumption and inflammatory markers.Design: The cross-sectional survey enrolled 1514 men ((x) over bar +/- SD age: 46 +/- 13 y; range: 18-87 y) and 1528 women (aged 45 +/- 13 y; range: 18-89 y). Five percent of men and 3% of women were excluded for history of CVD. Fasting blood samples were collected. Dietary habits (including consumption of various types of coffee) were evaluated by using a validated food-frequency questionnaire.Results: Compared with coffee nondrinkers, men who consumed >200 mL coffee/d had 50% higher interleukin 6 (IL-6), 30% higher C-reactive protein (CRP), 12% higher serum amyloid-A (SAA), and 28% higher tumor necrosis factor alpha (TNF-alpha) concentrations and 3% higher white blood cell (WBC) counts (all: P < 0.05). Women who consumed >200 mL coffee/d had 54% higher IL-6, 38% higher CRP, 28% higher SAA, and 28% higher TNF-alpha concentrations and 4% higher WBC counts (all: P < 0.05) than did coffee nondrinkers. The findings were significant even after control for the interactions between coffee consumption and age, sex, smoking, body mass index, physical activity status, and other covariates.Conclusions: A relation exists between moderate-to-high coffee consumption and increased inflammation process. This relation could explain, in part, the effect of increased coffee intake on the cardiovascular system.