Temporal and spectral properties of esophageal mucosal blood perfusion: a comparison between normal subjects and nutcracker esophagus patients.
Temporal and spectral properties of esophageal mucosal blood perfusion: a comparison between normal subjects and nutcracker esophagus patients.
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DOI：
10.1111/nmo.12917
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发表时间：
2017-03
影响因子：
3.5
通讯作者：
Mittal RK
中科院分区：
文献类型：
--
作者：
Zifan A;Jiang Y;Mittal RK
胡桃夹食道（NE）和其他食道运动障碍患者的食道疼痛机制尚不清楚。我们最近的研究表明，基线食管粘膜灌注，测量激光多普勒灌注监测（LDPM），是较低的NE患者相比，对照组。我们目前研究的目的是对NE患者和对照组的食管粘膜血液灌注（EMBP）波形进行更详细的分析，以确定最佳的EMBP生物标志物，结合合适的统计学习模型，在两组之间产生鲁棒的区分。10名正常受试者（平均年龄43 ±15岁，8名男性）和10名患者（平均年龄47± 5.5岁，8例男性）。从EMBP波形的前20分钟记录中提取时域和频域特征，根据四个独立的评价标准进行统计排名，并使用两种统计学习模型，即逻辑回归（LR）和支持向量机（SVM）进行分析。两组之间排名前3位的预测因子是0.5和0.75灌注分位数值，其次是频域中EMBP功率谱的表面。ROC曲线排序产生了SVM的0.93和LR的0.90的交叉验证AUC（曲线下面积）。我们发现，作为一个组NE患者有较低的灌注值相比，对照组，然而，有两组之间的重叠，这表明并非所有NE患者患有低粘膜灌注水平。我们研究的目的是对NE患者和对照组的食管粘膜血液灌注（EMBP）波形进行详细的时域和谱域分析，以确定最佳的EMBP生物标志物，该生物标志物与合适的统计学习模型相结合，可以在两组之间产生鲁棒的区分。
The mechanism of esophageal pain in patients with nutcracker esophagus (NE) and other esophageal motor disorders is not known. Our recent study shows that baseline esophageal mucosal perfusion, measured by laser Doppler perfusion monitoring (LDPM), is lower in NE patients compared to controls. The goal of our current study was to perform a more detailed analysis of esophageal mucosal blood perfusion (EMBP) waveform of NE patients and controls to determine the optimal EMBP biomarkers that combined with suitable statistical learning models produce robust discrimination between the two groups. Laser Doppler recordings of 10 normal subjects (mean age 43 ±15 years, 8 males) and ten patients (mean age 47± 5.5 yrs., 8 males) with NE were analyzed. Time and frequency domain features were extracted from the first twenty-minute recordings of the EMBP waveforms, statistically ranked according to four independent evaluation criterions, and analyzed using two statistical learning models, namely, logistic regression (LR) and support vector machines (SVM). The top 3 ranked predictors between the two groups were the 0.5 and 0.75 perfusion quantile values followed by the surface of the EMBP power spectrum in the frequency domain. ROC curve ranking produced a cross-validated AUC (area under the curve) of 0.93 for SVM and 0.90 for LR. We show that as a group NE patients have lower perfusion values compared to controls, however, there is an overlap between the two groups, suggesting that not all NE patients suffer from low mucosal perfusion levels. The goal of our study was to perform a detailed time and spectral domain analysis of the esophageal mucosal blood perfusion (EMBP) waveform from of NE patients and controls to determine the optimal EMBP biomarkers that combined with suitable statistical learning models may produce robust discrimination between the two groups.
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影响因子：
9.8
作者：
Dogan, Ibrahim;Puckett, James L.;Mittal, Ravinder K.
通讯作者：
Mittal, Ravinder K.
影响因子：
7.8
作者：
Vidaurre, Carmen;Kraemer, Nicole;Schloegl, Alois
通讯作者：
Schloegl, Alois
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
DOI：
10.1152/ajpgi.00359.2015
发表时间：
2016-03-15
影响因子：
4.5
作者：
Jiang, Yanfen;Mittal, Ravinder K.
通讯作者：
Mittal, Ravinder K.
DOI：
10.1061/(asce)0733-9429(2002)128:1(117
发表时间：
2002-01-01
期刊：
JOURNAL OF HYDRAULIC ENGINEERING-ASCE
影响因子：
--
作者：
Goring, DG;Nikora, VI
通讯作者：
Nikora, VI