Hyperintense Dentate Nucleus on Unenhanced T1-weighted MR Images Is Associated with a History of Brain Irradiation
Hyperintense Dentate Nucleus on Unenhanced T1-weighted MR Images Is Associated with a History of Brain Irradiation
复制标题
DOI：
10.1148/radiol.10100508
复制
发表时间：
2011-01-01
期刊：
影响因子：
19.7
通讯作者：
Togashi, Kaori
中科院分区：
文献类型：
--
作者：
Kasahara, Seiko;Miki, Yukio;Togashi, Kaori
目的：评估t1加权磁共振（MR）图像上齿状核高强度的频率，并建立这种高强度与临床因素（包括脑辐照史）之间的相关性。材料和方法：本研究经机构审查委员会批准，每位患者提供书面知情同意书。对362例患者（男性164例，女性198例，平均年龄62岁）进行了评估。使用3.0 t的自旋回波序列获得未增强的t1加权MR图像，两名对临床数据不知情的神经放射科医生独立评估齿状核的信号强度与小脑中央白质的信号强度，采用4分分级反应量表（4级表示明显的高强度，3级表示微弱的高强度，2级表示等强度，1级表示低强度）。采用后向逐步回归分析评价信号强度分级与以下临床因素的关系：性别、年龄、年龄与性别的相互作用、高血压、血脂异常、糖尿病、肝功能障碍、脑梗死、脑肿瘤、脊髓小脑变性、多发性硬化症、化疗史、脑辐照史。结果：362例患者中有41例（11%）出现t1高强度齿状核。41例患者中，31例（76%）有脑辐照史。t1加权MR图像上齿状核信号强度等级与脑辐照史显著相关（P < 0.001），其他临床因素无显著相关性。结论：在一些患者的非增强t1加权MR图像上可看到高强度的齿状核，可能与脑辐照史有关。(c) rsna, 2010
Purpose: To assess the frequency of hyperintensity in the dentate nucleus on T1-weighted magnetic resonance (MR) images and to establish correlations between such hyperintensity and clinical factors, including a history of brain irradiation.Materials and Methods: This study was approved by the institutional review board, and each patient provided written informed consent. Three hundred sixty-two patients (164 men, 198 women; mean age, 62 years) were evaluated. Unenhanced T1-weighted MR images were obtained by using a spin-echo sequence at 3.0 T. Two neuroradiologists, who were blinded to clinical data, independently evaluated the signal intensity of the dentate nucleus compared with the signal intensity of the central white matter of the cerebellum by using a four-point graded response scale (grade 4 indicated prominent hyperintensity; grade 3, faint hyperintensity; grade 2, isointensity; and grade 1, hypointensity). Backward stepwise regression analysis was used to evaluate the relationship between signal intensity grades and the following clinical factors: sex, age, the interaction between age and sex, hypertension, dyslipidemia, diabetes mellitus, liver dysfunction, brain infarction, brain tumor, spinocerebellar degeneration, multiple sclerosis, a history of chemotherapy, and a history of brain irradiation.Results: T1-hyperintense dentate nuclei were present in 41 (11%) of the 362 patients. Of these 41 patients, 31 (76%) had a history of brain irradiation. Signal intensity grade of the dentate nucleus on T1-weighted MR images correlated significantly with a history of brain irradiation (P < .001) but no other clinical factor.Conclusion: A hyperintense dentate nucleus may be seen on unenhanced T1-weighted MR images in some patients and may be associated with a history of brain irradiation. (C) RSNA, 2010