DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder.
DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder.
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DOI：
10.1017/s146114571300045x
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发表时间：
2013-10
期刊：
影响因子：
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通讯作者：
Drevets WC
中科院分区：
文献类型：
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作者：
Savitz J;Hodgkinson CA;Martin-Soelch C;Shen PH;Szczepanik J;Nugent AC;Herscovitch P;Grace AA;Goldman D;Drevets WC
DRD 2/ANKK 1 Taq 1A多态性的A1等位基因（rs 1800497）与健康个体（Con）纹状体D2/3受体结合减少以及抑郁和成瘾相关。然而，rs 1800497对抑郁症患者D2/3受体结合的影响以及SNP对奖励相关多巴胺释放过程中D2/3结合的影响尚不清楚。12名未接受药物治疗的重度抑郁症（MDD）患者和24名Con患者完成了[11 C]雷氯必利的PET扫描，一次没有接受金钱奖励（基线），一次在赢钱时。在Con中，A1等位基因与尾状核中部和腹侧纹状体的基线结合电位（BPND）降低相关。然而，在MDD患者中，A1等位基因与这些区域的基线BPND增加相关。rs 1800497与奖赏相关多巴胺释放过程中BPND的变化之间没有显著相关性。可以想象，A1等位基因通过其对突触后D2受体的作用而易患抑郁症和成瘾。
The A1 allele of the DRD2/ANKK1 Taq1A polymorphism (rs1800497) is associated with reduced striatal D2/3 receptor binding in healthy individuals (Con) as well as depression and addiction. However, the effect of rs1800497 on D2/3 receptor binding in depressed patients as well as the SNP’s effect on D2/3 binding during reward-associated dopamine release is unknown. Twelve unmedicated patients with major depressive disorder (MDD) and 24 Con completed PET scans with [11C]raclopride, once without receiving monetary rewards (baseline) and once while winning money. In Con, the A1 allele was associated with reduced baseline binding potential (BPND) in the middle caudate and ventral striatum. However, in MDD patients the A1 allele was associated with increased baseline BPND in these regions. There were no significant associations between rs1800497 and change in BPND during reward-associated dopamine release. Conceivably, the A1 allele predisposes to depression and addiction via its effect on the post-synaptic D2 receptor.