Antigen recognition by class I-restricted T lymphocytes.
Antigen recognition by class I-restricted T lymphocytes.
复制标题
I 类限制性 T 淋巴细胞的抗原识别。
DOI：
10.1146/annurev.iy.07.040189.003125
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发表时间：
1989
影响因子：
29.7
通讯作者：
H. Bodmer
中科院分区：
文献类型：
--
作者：
and A Townsend;H. Bodmer
这里讨论的工作提供了一个统一的观点T细胞识别，并表明，I类和II类分子有一个密切相关的功能，在介绍肽T淋巴细胞。在4-6小时裂解试验中用肽确定的I类限制性T细胞识别的表位都来源于病毒感染或转染细胞表达的内源性合成蛋白。越来越多的证据表明，细胞质降解系统可能参与这些表位的产生。用合成肽对CTL应答的特异性的分析已经证明了I类基因对分离的表位的免疫应答的控制和单个I类限制性表位的受体库的巨大多样性。
The work discussed here offers a unified view of T-cell recognition and suggests that class-I and class-II molecules have a closely related function in the presentation of peptides to T lymphocytes. The epitopes recognized by class I-restricted T cells that have been defined with peptides in the 4-6 hr lysis assay have all been derived from endogenously synthesized proteins expressed by virus infected or transfected cells. Evidence is accumulating that a cytoplasmic degradation system may be involved in the generation of these epitopes. The analysis of the specificity of CTL responses with synthetic peptides has demonstrated the control of immune responses to isolated epitopes by class-I genes and the great diversity of the receptor repertoire for individual class-I-restricted epitopes.
影响因子：
56.9
作者：
BACHMAIR, A;FINLEY, D;VARSHAVSKY, A
通讯作者：
VARSHAVSKY, A