Mitophagy is induced by short ubiquitin chains on mitochondria.

Mitophagy is induced by short ubiquitin chains on mitochondria.
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线粒体自噬是由线粒体上的短泛素链诱导的。

DOI:
10.1083/jcb.202008031
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发表时间:
2020
期刊:
J Cell Biol.
影响因子:
--
通讯作者:
Ikeda F.
Ikeda F.
中科院分区:
--
文献类型:
--
作者:
Ikeda F.

文献摘要

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线粒体自噬通过清除受损的线粒体在维持细胞内稳态方面具有关键作用。在这个问题上,Yamano et al.(2020. J. Cell Biol. https://doi.org/10.1083/jcb.201912144)揭示了自噬适配器视神经磷酸酶和膜蛋白ATG9A的新型复合物特异性地调节泛素诱导的线粒体自噬。
Mitophagy has a critical role in maintaining cellular homeostasis by removing damaged mitochondria. In this issue, Yamano et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.201912144) uncover that a novel complex of the autophagy adaptor optineurin and the membrane protein ATG9A specifically regulate ubiquitin-induced mitophagy.