Nephropathy and establishment of a renal reservoir of HIV type 1 during primary infection
Nephropathy and establishment of a renal reservoir of HIV type 1 during primary infection
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DOI：
10.1056/nejm200106283442604
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发表时间：
2001-06-28
影响因子：
158.5
通讯作者：
Klotman, ME
中科院分区：
文献类型：
--
作者：
Winston, JA;Bruggeman, LA;Klotman, ME
人类免疫缺陷病毒1型(HIV-1)相关性肾病是HIV-1感染患者慢性肾脏疾病的主要原因，现在是20岁至年龄段黑人终末期肾脏疾病的第三大原因。1、2这些患者通常有蛋白尿，随后肾小球滤过率降低，在几周或几个月后进展为终末期肾病。HIV-1相关性肾病的形态特征是局灶性节段性肾小球硬化、肾小管微囊、间质纤维化和炎症。2-5 HIV-1相关性肾病的发病机制尚不清楚，但越来越多的证据表明它是由HIV-1感染引起的。
Human immunodeficiency virus type 1 (HIV-1)–associated nephropathy is the chief cause of chronic renal disease in patients with HIV-1 infection and is now the third leading cause of end-stage renal disease in blacks 20 to 64 years of age.1,2These patients typically have proteinuria followed by a reduction in the glomerular filtration rate that progresses to end-stage renal disease in a few weeks or months. HIV-1–associated nephropathy is characterized morphologically by focal segmental glomerulosclerosis, tubular microcysts, interstitial fibrosis, and inflammation.2–5The pathogenesis of HIV-1–associated nephropathy is poorly understood, but increasing evidence suggests it is due to HIV-1 infection . . .