INTERLEUKIN-1-LIKE ACTIVITIES IN SYNOVIAL-FLUIDS OF PATIENTS WITH RHEUMATOID-ARTHRITIS AND TRAUMATIC SYNOVITIS
INTERLEUKIN-1-LIKE ACTIVITIES IN SYNOVIAL-FLUIDS OF PATIENTS WITH RHEUMATOID-ARTHRITIS AND TRAUMATIC SYNOVITIS
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DOI：
10.1007/bf00270301
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发表时间：
1985-01-01
影响因子：
4
通讯作者：
INGEMANNHANSEN, T
中科院分区：
文献类型：
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作者：
BENDTZEN, K;PETERSEN, J;INGEMANNHANSEN, T
生物体液中的白细胞介素-1（IL-1）样活性通过其将高度纯化的T淋巴细胞的IL-1依赖性淋巴因子产生纠正为回忆抗原的能力来测量。IL-1样活性在9/11例类风湿关节炎（RA）患者的滑液（SF）标本中发现，但仅在2/11配对的RA血清。在创伤性滑膜炎，低IL-1样活性记录在5的9 SF标本，和类似的低活性被发现在这些患者的血清中的4。IL-1样活性部分被抗IL-1抗体吸收。RA患者SF中IL-1的存在表明单核细胞/巨噬细胞的体内活化。
Interleukin-1 (Il-1)-like activity in biological fluids was measured by their ability to rectify the Il-1-dependent lymphokine production of highly purified T lymphocytes to a recall antigen. Il-1-like activity was found in 9 of 11 synovial fluid (SF) specimens from patients with rheumatoid arthritis (RA) but only in 2 of 11 paired RA sera. In traumatic synovitis, low Il-1-like activity was recorded in 5 of 9 SF specimens, and a similar low activity was found in sera of 4 of these patients. The Il-1-like activity was partly absorbed by an anti-Il-1 antibody. The presence of Il-1 in the SF of patients with RA suggests in vivo activation of monocytes/macrophages.