Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
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DOI：
10.1172/jci37385
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发表时间：
2009-05-01
影响因子：
15.9
通讯作者：
Havel, Peter J.
中科院分区：
文献类型：
--
作者：
Stanhope, Kimber L.;Schwarz, Jean Marc;Havel, Peter J.
动物研究已经证明，与葡萄糖相比，膳食果糖会导致血脂异常和胰岛素抵抗。为了评估这些膳食糖在人类持续摄入过程中的相对影响，超重和肥胖受试者饮用葡萄糖或果糖甜味饮料，提供10周25%的能量需求。虽然两组在干预期间表现出相似的体重增加，但内脏脂肪体积仅在摄入果糖的受试者中显着增加。空腹血浆甘油三酯浓度增加约10%，在10周的葡萄糖消费，但不是果糖消费后。相比之下，肝脏新生脂肪生成（DNL）和23小时餐后甘油三酯AUC增加，特别是在果糖消费。同样，改变脂质代谢和脂蛋白重塑的标志物，包括空腹载脂蛋白B，低密度脂蛋白，低密度脂蛋白，氧化低密度脂蛋白，和餐后浓度的残余样颗粒甘油三酯和胆固醇显着增加果糖，但不是葡萄糖的消费。此外，空腹血糖和胰岛素水平增加，胰岛素敏感性下降，在受试者消耗果糖，而不是在那些消耗葡萄糖。这些数据表明，膳食果糖特别增加DNL，促进血脂异常，降低胰岛素敏感性，并增加超重/肥胖成年人的内脏肥胖。
Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle-triglyceride and -cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.