Structural brain correlates of response inhibition in Bipolar Disorder I
Structural brain correlates of response inhibition in Bipolar Disorder I
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DOI：
10.1177/0269881107082955
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发表时间：
2008-03-01
影响因子：
4.1
通讯作者：
Frangou, Sophia
中科院分区：
文献类型：
--
作者：
Haldane, Morgan;Cunningham, Giles;Frangou, Sophia
反应抑制缺陷是I型双相情感障碍的一个显著特征。本研究的目的是探讨抑制控制与脑结构之间的关系，以帮助我们了解BDI的病理生理学机制。采用Stroop颜色词任务的干扰分数和Hayling句子补全测验的总错误分数，对BDI缓解期患者(n=44)和健康对照组(n=44)的抑制控制进行了测量。还对所有参与者进行了结构磁共振成像脑部扫描。在这两项指标中，控制组较好的表现与背侧和腹侧前额叶皮质(PFC)区的灰质体积呈正相关，干扰分数还显示了顶叶受累。相比之下，BDI患者较好的抑制性控制与右侧顶叶皮质区域的灰质体积呈正相关，即楔形脑区代表总错误分数，顶下小叶代表干扰分数。在BDI患者中，PFC灰质与抑制控制措施之间缺乏相关性提示PFC功能障碍；反应抑制与顶叶灰质体积之间的相关性可能表明BDI患者顶叶皮质代偿性受累。
Deficits in response inhibition are a prominent feature of Bipolar Disorder, type I ( BDI). The purpose of this study was to examine the relationship between inhibitory control and cerebral structure as it may inform our understanding of the pathophysiology of BDI. Inhibitory control was measured in remitted patients with BDI ( n=44) and healthy controls ( n=44), using the interference score from the Stroop Colour Word Task and the scaled total error score from the Hayling Sentence Completion Test. Structural magnetic resonance imaging brain scans were also obtained for all participants. For both measures, better performance in controls correlated positively with gray matter volume in the dorsal and ventral prefrontal cortical ( PFC) regions with parietal involvement additionally seen for the interference score. In contrast, better inhibitory control in BDI patients correlated positively with gray matter volume in the right parietal cortical regions, namely the cuneus for the scaled total error score and the inferior parietal lobule for the interference score. The observed lack of correlation between PFC grey matter and measures of inhibitory control in BDI patients is suggestive of PFC dysfunction; the correlation between response inhibition and parietal grey matter volume may be indicative of a compensatory involvement of the parietal cortices in BDI.