Slower decline of glomerular filtration rate in the Japanese general population: A longitudinal 10-year follow-up study
Slower decline of glomerular filtration rate in the Japanese general population: A longitudinal 10-year follow-up study
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DOI：
10.1291/hypres.31.433
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发表时间：
2008-03-01
影响因子：
5.4
通讯作者：
Matsuo, Seiichi
中科院分区：
文献类型：
--
作者：
Imai, Enyu;Horio, Masaru;Matsuo, Seiichi
日本 3 至 5 期慢性肾病 (CKD) 的患病率 (18.7%) 远高于美国 (4.5%)。这项研究在日本普通人群中调查了这种较高的 CKD 患病率是否可能反映了肾功能的进行性下降，进而导致终末期肾病的风险增加。对参加1988-1993年和1998-2003年这两个时期的年度健康检查计划的120,727名40岁以上的人进行了10年以上肾功能下降的检查。使用经日本系数修改的简化的肾病饮食修改（MDRD）研究方程，根据估计的肾小球滤过率（GFR）评估肾功能。参与者的 GFR 平均下降率为 0.36 mL/min/1.73 m(2)/年。在50-79岁的男性人群中，存在高血压的情况下GFR平均下降率显着高于不存在高血压的情况。无论男女，有蛋白尿的参与者的 GFR 下降率均比无蛋白尿的参与者高出两倍多。初始 GFR 的参与者中该比率明显更高
The prevalence of stage 3 to 5 chronic kidney disease (CKD) in Japan (18.7%) is considerably higher than that in the United States (4.5%). This study investigated in the Japanese general population whether this higher prevalence of CKD might reflect to a progressive decline of renal function, and in turn to the increased risk of end-stage renal disease. A decline in renal function over 10 years was examined in 120,727 individuals aged 40 years or older who participated in the annual health examination program of the two periods over 10 years, 1988-1993 and 1998-2003. Renal function was assessed with estimated glomerular filtration rate (GFR) using the abbreviated Modification of Diet in Renal Disease (MDRD) Study equation modified by a Japanese coefficient. The rate of GFR decline in the participants was 0.36 mL/min/1.73 m(2)/year on average. In the male population aged 50-79, the mean rate of GFR decline was significantly higher in the presence of hypertension than in its absence. The rate of GFR decline was more than two times higher in participants with proteinuria than in those without proteinuria in both sexes. The rate was significantly higher in participants with an initial GFR