Accumulation of hippocampal place fields at the goal location in an annular watermaze task
Accumulation of hippocampal place fields at the goal location in an annular watermaze task
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DOI：
10.1523/jneurosci.21-05-01635.2001
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发表时间：
2001-03-01
影响因子：
5.3
通讯作者：
Moser, EI
中科院分区：
文献类型：
--
作者：
Hollup, SA;Molden, S;Moser, EI
为了探索空间选择性海马锥体神经元中信息的可塑性表征，我们在大鼠中进行了多个单单位记录，这些大鼠被训练在依赖于海马的环形水迷宫任务中在恒定位置找到隐藏的平台。海马锥体细胞在水迷宫中表现出位置相关的放电。即使在没有立即逃逸的探测试验中，位置场也倾向于在平台附近积累。在隐藏平台周围，细胞活跃度最高的百分比是竞技场其他同样大的区域的两倍多。该效果与平台在房间框架中的实际位置无关。它与正在进行的运动行为无关，与线速度或角速度、游泳方向或海马theta活动的变化无关。在接受可变平台位置训练的大鼠中，任何特定区域都没有放电累积。这些训练依赖性效应表明，特定行为意义的区域可能在海马空间图中过度表现，即使这些区域完全没有标记。
To explore the plastic representation of information in spatially selective hippocampal pyramidal neurons, we made multiple single-unit recordings in rats trained to find a hidden platform at a constant location in a hippocampal-dependent annular watermaze task. Hippocampal pyramidal cells exhibited place-related firing in the watermaze. Place fields tended to accumulate near the platform, even in probe trials without immediate escape. The percentage of cells with peak activity around the hidden platform was more than twice the percentage firing in equally large areas elsewhere in the arena. The effect was independent of the actual position of the platform in the room frame. It was dissociable from ongoing motor behavior and was not related to linear or angular speed, swim direction, or variation in hippocampal theta activity. There was no accumulation of firing in any particular region in rats that were trained with a variable platform location. These training-dependent effects suggest that regions of particular behavioral significance may be over-represented in the hippocampal spatial map, even when these regions are completely unmarked.