Micro- and nano-bone analyses of the human mandible coronoid process and tendon-bone entheses
Micro- and nano-bone analyses of the human mandible coronoid process and tendon-bone entheses
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人类下颌骨冠突和腱骨附着点的微米和纳米骨分析
DOI：
10.1002/jbm.b.34609
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Hattori Masayuki
中科院分区：
文献类型：
--
作者：
Kasahara Masaaki;Matsunaga Satoru;Someya Tomoko;Kitamura Kei;Odaka Kento;Ishimoto Takuya;Nakano Takayoshi;Abe Shinichi;Hattori Masayuki
喙突附着于颞肌和咬肌，在咀嚼运动中起重要作用。肌腱连接肌肉和骨骼，介导功能负荷到骨骼的传递。因此，腱-骨附着点控制骨骼中的机械应力。生物磷灰石（biological apatite，BAp）微晶是骨中的主要矿物成分，其择优取向是评价骨质量和功能的重要指标，并在很大程度上受局部应力的影响。在这项研究中，我们分析了BAp方向，杨氏模量，骨密度（BMD）在不同的网站在人类冠状突。在分析的网站之间没有发现BMD的差异，但观察到的BAp晶体取向不同。BAp微晶在冠状突尖处显示出近远中方向的单向取向，但在其他部位则以垂直于咬合平面的方向取向。杨氏模量倾向于根据BAp取向而变化。在顶点处，观察到肌腱形式具有不同于其他部位的特征，包括存在纤维软骨层，其可作为拉伸制动器以控制应力集中。这些发现表明颞肌的功能性压力影响骨质量和强度。
The coronoid process provides attachment to temporalis and masseter muscles, and thus plays an important role in mastication. Tendons connect muscles and bones, mediating the transmission of functional loads to bones. Thus, tendon–bone entheses govern mechanical stress in bones. The preferential orientation of biological apatite (BAp) crystallites, the main mineral component in bones, is an important index for bone quality and function, and is largely influenced by locally applied stress. In this study, we analyzed BAp orientation, Young's modulus, and bone mineral density (BMD) at different sites in the human coronoid process. No differences in BMD were found among the analyzed sites, but BAp crystal orientation was observed to differ. BAp crystallites showed a uni‐directional orientation in the mesiodistal direction at the coronoid process apex, but were oriented in the direction vertical to the occlusal plane at other sites. Young's modulus tended to vary according to the BAp orientation. At the apex, a tendon form with characteristics different from those at other sites, including the presence of a fibrocartilaginous layer that may act as a stretching brake to control stress concentration, was observed. These findings suggest that the functional pressure of the temporalis muscle affects bone quality and strength.