Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats
Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats
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DOI：
10.1152/ajpendo.90796.2008
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发表时间：
2009-04-01
影响因子：
5.1
通讯作者：
Raybould, Helen E.
中科院分区：
文献类型：
--
作者：
Paulino, Gabriel;de la Serre, Claire Barbier;Raybould, Helen E.
Paulino G, Barbier de la Serre C, knottts TA, Oort PJ, Newman JW, Adams SH, Raybould HE。饮食诱导肥胖大鼠结节神经节中增氧因子受体的表达增加。[J] .中国生物医学工程学报，2009,31(2):387 - 398。2009年2月3日首次发表；doi: 10.1152 / ajpendo.90796.2008。迷走神经传入通路在食物摄入的短期调节中很重要，长期摄入高脂肪饮食导致该神经通路的激活降低可能导致食源性增重。我们验证了这样一种假设，即迷走神经传入神经元中编码促氧因子受体的基因表达通过长期摄入高脂肪饮食而增加，从而支持来自肠道的促氧信号。与低脂饮食对照组和高脂饮食诱导的肥胖抵抗（DIO-R）大鼠相比，高脂饮食喂养的肥胖易感性（DIO-P）大鼠体重增加，高瘦素血症升高。与低脂饮食喂养的对照组或DIO-R大鼠相比，DIO-P中结节神经节中I型大麻素受体和生长激素促分泌素受体1a的表达增加。迷走神经传入通路中厌氧和厌氧信号平衡的改变可能影响高脂肪饮食引起的食物摄入和体重增加。
Paulino G, Barbier de la Serre C, Knotts TA, Oort PJ, Newman JW, Adams SH, Raybould HE. Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats. Am J Physiol Endocrinol Metab 296: E898-E903, 2009. First published February 3, 2009; doi:10.1152/ajpendo.90796.2008.-The vagal afferent pathway is important in short-term regulation of food intake, and decreased activation of this neural pathway with long-term ingestion of a high-fat diet may contribute to hyperphagic weight gain. We tested the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high-fat diet, thus supporting orexigenic signals from the gut. Obesity-prone (DIO-P) rats fed a high-fat diet showed increased body weight and hyperleptinemia compared with low-fat diet-fed controls and high-fat diet-induced obesity-resistant (DIO-R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor 1a in the nodose ganglia was increased in DIO-P compared with low-fat diet-fed controls or DIO-R rats. Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.