Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.
Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseases.
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DOI：
10.1111/j.1742-4658.2011.08235.x
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Tiwari AK
中科院分区：
文献类型：
--
作者：
Chen ZS;Tiwari AK
三磷酸腺苷结合盒转运体(ABC)是膜蛋白的一个超家族，以其通过三磷酸腺苷(ATP)水解酶以浓度梯度跨膜转运多种外源和内源物质而著称。人类ABC转运蛋白有7个亚家族，其中最大的是C亚家族(基因符号ABCC)。9个ABCC亚家族成员，即所谓的多药耐药蛋白(MRPs)1-9，随着肿瘤细胞外排出化疗药物(或其代谢产物)，不同程度地参与了肿瘤细胞的多药耐药。一些MRP还被认为影响药物在正常组织中的处置，或通过肝胆或肾脏排泄途径调节药物(或其代谢物)的消除。此外，白三烯C4和cAMP等生理上重要的有机阴离子的细胞外流是由一个或多个MRP介导的。最后，几个MRP的突变与人类遗传疾病有关。本文就MRP1-MRP9在肿瘤化疗和人类遗传病中的生化和生理学知识进行综述。MRP2/ABCC2基因突变导致高胆红素血症(Dubin-Johnson综合征)和MRP6/ABCC6基因突变导致结缔组织疾病弹性假黄色素瘤也被讨论。
The ATP-binding cassette (ABC) transporters are a superfamily of membrane proteins that are best known for their ability to transport a wide variety of exogenous and endogenous substances across membranes against a concentration gradient via ATP hydrolysis. There are seven subfamilies of human ABC transporters, one of the largest being the ‘C’ subfamily (gene symbol ABCC). Nine ABCC subfamily members, the so-called Multidrug Resistance Proteins (MRPs) 1-9, have been implicated in mediating multidrug resistance in tumor cells to varying degrees as the efflux extrude chemotherapeutic compounds (or their metabolites) from malignant cells. Some of the MRPs are also known to either influence drug disposition in normal tissues or modulate the elimination of drugs (or their metabolites) via hepatobiliary or renal excretory pathways. In addition, the cellular efflux of physiologically important organic anions such as leukotriene C4 and cAMP is mediated by one or more of the MRPs. Finally, mutations in several MRPs are associated with human genetic disorders. In this review article, the current biochemical and physiological knowledge of MRP1-MRP9 in cancer chemotherapy and human genetic disease is summarized. The mutations in MRP2/ABCC2 leading to conjugated hyperbilirubinemia (Dubin-Johnson syndrome) and in MRP6/ABCC6 leading to the connective tissue disorder Pseudoxanthoma elasticum are also discussed.
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影响因子：
5.7
作者：
Bera, TK;Lee, S;Pastan, I
通讯作者：
Pastan, I
影响因子：
3.3
作者：
Bortfeld, M;Rius, M;Keppler, D
通讯作者：
Keppler, D
影响因子：
3.6
作者：
Chen, ZS;Hopper-Borge, E;Kruh, GD
通讯作者：
Kruh, GD
DOI：
10.1093/jnci/90.22.1735
发表时间：
1998-11-18
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Belinsky, MG;Bain, LJ;Kruh, GD
通讯作者：
Kruh, GD
影响因子：
3.6
作者：
Bandler, Paul E.;Westlake, Christopher J.;Deeley, Roger G.
通讯作者：
Deeley, Roger G.