CORRELATION BETWEEN COMPUTED TOMOGRAPHIC BRAIN-SCAN ABNORMALITIES AND NEUROPSYCHOLOGICAL FUNCTION IN CHILDREN WITH SYMPTOMATIC HUMAN-IMMUNODEFICIENCY-VIRUS DISEASE
CORRELATION BETWEEN COMPUTED TOMOGRAPHIC BRAIN-SCAN ABNORMALITIES AND NEUROPSYCHOLOGICAL FUNCTION IN CHILDREN WITH SYMPTOMATIC HUMAN-IMMUNODEFICIENCY-VIRUS DISEASE
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DOI：
10.1001/archneur.1995.00540250043011
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发表时间：
1995-01-01
影响因子：
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通讯作者：
PIZZO, P
中科院分区：
文献类型：
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作者：
BROUWERS, P;DECARLI, C;PIZZO, P
目的：评估在有症状的人类免疫缺陷病毒病儿童中观察到的计算机断层扫描脑扫描异常的临床意义。患者：87名既往未接受过治疗的有症状的人类免疫缺陷病毒1型疾病儿童。方法：认知功能的一般水平，从与年龄相适应的智力测试中获得，社会情感行为与计算机断层扫描脑扫描异常评级相关。结果：计算机断层扫描脑扫描异常和认知功能障碍以及异常行为之间存在显着关系，与输血感染患者相比，（年轻）垂直感染儿童的关系更强。钙化，独立于脑萎缩的程度，与显着更大的延迟neurocognitive development.Conclusion：计算机断层扫描脑扫描异常，即使是轻微的，具有临床意义，这表明，人类免疫缺陷病毒相关的中枢神经系统的妥协是一个连续的过程，扫描可能是有帮助的，在基线定义患者的风险，并在治疗过程中监测他们。
Objective: To evaluate the clinical significance of computed tomographic brain scan abnormalities observed in children with symptomatic human immunodeficiency virus disease.Patients: Eighty-seven previously untreated children with symptomatic human immunodeficiency virus type 1 disease.Methods: General levels of cognitive functioning, obtained from age-appropriate intelligence tests, and social-emotional behavior were correlated with computed tomographic brain scan abnormality ratings.Results: A significant relation between computed tomographic brain scan abnormalities and cognitive dysfunction as well as aberrant behavior was found, which appeared stronger in (younger) vertically infected children compared with transfusion-infected patients. Calcifications, independent from the degree of brain atrophy, were associated with significantly greater delays in neurocognitive development.Conclusion: Computed tomographic brain scan abnormalities, even when mild, were of clinical significance, suggesting that human immunodeficiency virus-associated central nervous system compromise is a continuous process and that scans may be helpful at baseline in defining patients at risk and for monitoring them during therapy.