Vessel Size Imaging Using Dual Contrast Agent Injections
Vessel Size Imaging Using Dual Contrast Agent Injections
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DOI：
10.1002/jmri.21960
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发表时间：
2009-11-01
影响因子：
4.4
通讯作者：
Liu, Ho-Ling
中科院分区：
文献类型：
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作者：
Hsu, Yuan-Yu;Yang, Wei-Shan;Liu, Ho-Ling
目的：探讨血管尺寸成像（VSI）技术的可行性与单独的造影剂注射的血管口径在正常组织和脑tumors.Materials和Methods的评价：计算机模拟进行第一次评估的潜在错误，在估计血管口径，可能会导致从双重造影剂注射之间的时间偏移。招募了八名患有脑肿瘤（三名高级别胶质瘤，两名低级别胶质瘤和三名脑膜瘤）的患者（四名女性，四名男性，37-77岁）进行临床研究。在3.0T扫描仪上分别使用梯度回波（GE）和自旋回波（SE）回波平面成像序列进行动态磁敏感对比磁共振成像（MRI），间隔10分钟。结果：计算机模拟结果表明，当GE和SE的峰值时间差为1.5s时，血管管径测量误差小于8%，当两者的峰值时间差为1 s时，血管管径测量误差小于5%。根据64 x 64矩阵的患者数据集，皮质灰质的估计血管口径为37.4 +/- 12.9 μ m，丘脑为20.7 +/- 8.8 μ m，白色物质为15.0 +/- 5.1 μ m，与文献结果相当。2例患者的VSI为128 x 128矩阵，正常组织的血管口径结果相似。所有肿瘤的平均血管直径均大于正常组织。正常组织和肿瘤之间的血管大小的差异，清楚地表明在两个VSI的规则和高空间resolution.Conclusion：这项研究表明，VSI与双注射方法是一种可行的技术，用于估计微血管口径的正常组织和脑肿瘤的临床扫描仪。
Purpose: To investigate the feasibility of a vessel size imaging (VSI) technique with separate contrast agent injections for evaluation of the vessel caliber in normal tissues and in brain tumors.Materials and Methods: Computer simulation was first per-formed to assess the potential errors in the estimation of vessel caliber that could result from time shifts between the dual contrast agent injections. Eight patients (four female, four male, 37-77 years old) with brain tumors (three high-grade gliomas, two low-grade gliomas, and three meningiomas) were recruited for clinical study. Dynamic susceptibility contrast magnetic resonance imaging (MRI) using gradient echo (GE) and spin echo (SE) echo-planar imaging sequences were performed separately with a 10-minute interval on a 3.0T scanner. Vessel caliber maps were calculated and analyzed in regions of interest at cortical gray matter (GM), thalamus, white matter (WM), and tumors.Results: From the computer simulation, the error of vessel caliber measurement was less than 8% when the difference between the time-to-peak of the GE and the SE studies was 1.5 seconds, and reduced to within 5% when the difference was 1 second. From the patient datasets of a 64 x 64 matrix, the estimated vessel calibers were 37.4 +/- 12.9 mu m for cortical gray matter, 20.7 +/- 8.8 mu m for thalamus, and 15.0 +/- 5.1 mu m for white matter, comparable to results in the literature. Two patients had a VSI with 128 x 128 matrix and showed similar results in vessel calibers of normal tissues. All the tumors had larger mean vessel diameter than normal-appearing tissues. The difference in vascular size between normal tissue and tumor was demonstrated clearly in both the VSIs of regular and high spatial resolution.Conclusion: This study suggests that VSI with a dual injection method is a feasible technique for estimating microvascular calibers of normal tissues and brain tumors in clinical scanners.