HPV infections among young MSM visiting sexual health centers in the Netherlands: Opportunities for targeted HPV vaccination
HPV infections among young MSM visiting sexual health centers in the Netherlands: Opportunities for targeted HPV vaccination
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DOI：
10.1016/j.vaccine.2020.03.002
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发表时间：
2020-04-09
期刊：
影响因子：
5.5
通讯作者：
Hoebe, Christian J. P. A.
中科院分区：
文献类型：
--
作者：
Woestenberg, Petra J.;van Benthem, Birgit H. B.;Hoebe, Christian J. P. A.
简介：2009年，荷兰引入了仅针对女孩的HPV 16/18疫苗接种，接种率达到46-61%。异性恋男性受益于群体保护，但目前尚不清楚与男性发生性关系的男性（MSM）是否也受益于仅针对女孩的HPV 16/18疫苗接种计划的群体效应。由于MSM承担着高HPV相关疾病负担，各国可能会考虑针对MSM的疫苗接种。为了研究可能的群体效应和在接种疫苗的潜在时刻之前的HPV暴露，我们评估了年轻MSM访问性健康中心（SHC）的各种疫苗类型的HPV患病率和比例（血清）阴性的趋势。在这项两年一次的横断面研究中，16-24岁的SHC访客中，MSM提供了阴茎和肛门拭子用于HPV DNA检测（包括HPV 6/11/16/18/31/33/45/52/58型疫苗）和HPV抗体检测用血液结果：共纳入MSM 575例，中位年龄22岁，终生性伴15例，HIV阳性率3.5%。2009-2017年期间，所有疫苗类型的阴茎或肛门HPV患病率趋势均无统计学意义。在455例MSM中，阴茎和肛门拭子中，360例（79%）、283例（62%）和242例（53%）在两个解剖部位的HPV 16/18、HPV 6/11/16/18和HPV 6/11/16/18/31/33/45/52/58分别为HPV DNA阴性。在HPV 16/18和HPV 16/18/31/33/45/52/58 DNA阴性的MSM中，（n = 335和279），82%和71%的相应类型的血清反应阴性。讨论：在引入仅针对女孩的HPV 16/18疫苗接种后的8年内，MSM中的HPV患病率没有显著下降，这表明男男性接触者不太可能从仅女孩接种疫苗的群体效应中获益。大多数MSM是疫苗型DNA阴性和血清阴性，这表明年轻MSM访问SHC的疫苗接种仍然是有益的。(C)2020作者（S）爱思唯尔有限公司出版
Introduction: In 2009, girls-only HPV16/18 vaccination was introduced in the Netherlands which has achieved 46-61% uptake. Heterosexual men have benefitted from herd protection, but it is unknown whether men who have sex with men (MSM) also benefit from herd effects of the girls-only HPV16/18 vaccination program. Because MSM bear a high HPV-related disease burden, countries might consider targeted vaccination for MSM. To study possible herd effects and prior HPV exposure at a potential moment of vaccination, we assessed trends in the HPV prevalence and proportions (sero)negative for the various vaccine types among young MSM visiting sexual health centers (SHCs).Methods: We used data from MSM included in PASSYON study years 2009-2017. In this biennial cross-sectional study among visitors of SHCs aged 16-24 years, MSM provided a penile and anal swab for HPV DNA testing (including vaccine types HPV6/11/16/18/31/33/45/52/58) and blood for HPV antibody testing (HPV16/18/31/33/45/52/58).Results: In total 575 MSM were included, with a median of 22 years of age and 15 lifetime sex partners and 3.5% HIV positive. Trends in penile or anal HPV prevalence during 2009-2017 were statistically non-significant for all vaccine types. Of the 455 MSM with a penile and anal swab, 360 (79%), 283 (62%) and 242 (53%) were HPV DNA negative at both anatomical sites for HPV16/18, HPV6/11/16/18 and HPV6/11/16/18/31/33/45/52/58 respectively. Among MSM who were HPV16/18 and HPV16/18/31/33/45/52/58 DNA negative and were tested for serology (n = 335 and 279 respectively), 82% and 71% were also seronegative for the respective types.Discussion: There were no significant declines in the HPV prevalence among MSM up to eight years after introduction of girls-only HPV16/18 vaccination, indicating that MSM are unlikely to benefit largely from herd effects from girls-only vaccination. Most MSM were vaccine-type DNA negative and seronegative, suggesting that vaccination of young MSM visiting SHCs could still be beneficial. (C) 2020 The Author(s). Published by Elsevier Ltd.