Evaluation of an Epitypified Ophiocordyceps formosana (Cordyceps s.l.) for Its Pharmacological Potential.
Evaluation of an Epitypified Ophiocordyceps formosana (Cordyceps s.l.) for Its Pharmacological Potential.
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DOI：
10.1155/2015/189891
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Shen TL
中科院分区：
文献类型：
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作者：
Wang YW;Hong TW;Tai YL;Wang YJ;Tsai SH;Lien PT;Chou TH;Lai JY;Chu R;Ding ST;Irie K;Li TK;Tzean SS;Shen TL
虫草的巨大优点spp.在医学上的益处在很大程度上得到了赞赏。然而，只有少数研究的特点和检查的临床并发症的使用保健补品含有这些物种。在这里，我们将C.根据形态学、分子系统发育分析及代谢物分析，将所收集之台湾蛇珊瑚分离株鉴定为台湾蛇珊瑚。因此，我们重新命名并转移了C。本文还对台湾蛇尾虫Ophiocorphium formosana（Kobayasi & Shimizu）Wang，Tsai，Tzean & Shen comb. nov.的药理作用进行了初步探讨。根据菌丝体的热水萃取物来评估福尔摩沙。已知的生物活性成分的相对量是独特的虫草s.l.种O. formosana的含量与O. sinensis和C. militaris，表明O.药用台湾产。此外，我们还发现O.在体外和体内的抗氧化活性与O. sinensis和C.军队。此外，O.与供试的冬虫夏草s.l.相比，台湾虫草也显示出显著有效的抗肿瘤活性。物种内蒂什岛台湾虫草的毒性较其他虫草品种为低。总之，我们的数据表明，O。福尔摩沙在辅助医学上扮演积极角色。
The substantial merit of Cordyceps s.l. spp. in terms of medicinal benefits is largely appreciated. Nevertheless, only few studies have characterized and examined the clinical complications of the use of health tonics containing these species. Here, we epitypified C. formosana isolates that were collected and characterized as Ophiocordyceps formosana based on morphological characteristics, molecular phylogenetic analyses, and metabolite profiling. Thus, we renamed and transferred C. formosana to the new protologue Ophiocordyceps formosana (Kobayasi & Shimizu) Wang, Tsai, Tzean & Shen comb. nov. Additionally, the pharmacological potential of O. formosana was evaluated based on the hot-water extract from its mycelium. The relative amounts of the known bioactive ingredients that are unique to Cordyceps s.l. species in O. formosana were found to be similar to the amounts in O. sinensis and C. militaris, indicating the potential applicability of O. formosana for pharmacological uses. Additionally, we found that O. formosana exhibited antioxidation activities in vitro and in vivo that were similar to those of O. sinensis and C. militaris. Furthermore, O. formosana also displayed conspicuously effective antitumor activity compared with the tested Cordyceps s.l. species. Intrinsically, O. formosana exhibited less toxicity than the other Cordyceps species. Together, our data suggest that the metabolites of O. formosana may play active roles in complementary medicine.