The risk of offspring developing substance use disorders when exposed to one versus two parent(s) with alcohol use disorder: A nationwide, register-based cohort study
The risk of offspring developing substance use disorders when exposed to one versus two parent(s) with alcohol use disorder: A nationwide, register-based cohort study
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DOI：
10.1016/j.jpsychires.2016.06.001
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发表时间：
2016-09-01
影响因子：
4.8
通讯作者：
Christiansen, Erik
中科院分区：
文献类型：
--
作者：
Mellentin, Angelina Isabella;Brink, Maria;Christiansen, Erik
目的：很少有基于人群的家庭研究探讨了接触一位或两位患有酒精使用障碍 (AUD) 的父母与后代患药物使用障碍 (SUD) 的风险之间的关联。此外，这些研究仅关注后代 AUD 的发育，而不是 SUD。本研究的目的是调查一对或两个患有 AUD 的父母是否会增加后代患 SUD 的风险。方法：进行了一项基于人群的队列研究，对 1983 年至 1989 年在丹麦出生的后代进行国家登记跟踪，直至 2011 年。基于登记的数据来自：精神病学中央研究登记处、国家患者登记处、民事登记系统、生育力数据库和死亡原因登记处。使用多元 Cox 回归模型计算调整后的危险比。结果：本研究总共纳入了 398,881 名后代。其中，3.9% 的父母至少有一位持有澳元。父母 AUD 与后代 SUD 的发展显着相关。父母一方患有 AUD 的风险增加 1.44 倍（95% CL，1.29-1.61），而父母两人患有 AUD 的风险增加 2.29 倍（95% Cl，1.64-3.20）。没有发现与父母或后代性别相关的显着差异。结论：接触父母 AUD 与后代患 SUD 的风险增加有关。对于暴露于双亲 AUD 的后代来说，这种风险是附加的。这些发现对于临床评估和干预策略以及暴露于父母 AUD 的后代的管理具有重要意义。 (C) 2016 Elsevier Ltd. 保留所有权利。
Aim: Few population-based, family studies have examined associations between exposure to one vs. two parent(s) with alcohol use disorder (AUD) and the risk of offspring developing substance use disorder (SUD). Moreover, these studies have focused solely on the development of AUD, and not SUD, in offspring. The purpose of this study was to investigate whether exposure to one vs. two parent(s) with AUD increases the risk of offspring developing SUD.Methods: A population-based, cohort study was conducted in which offspring born in Denmark between 1983 and 1989 were followed through national registries until 2011. Register-based data were obtained from the: Psychiatric Central Research Register, National Patient Registry, Civil Registration System, Fertility Database, and Cause of Death Register. Adjusted hazard ratios were calculated using multivariate Cox-regression models.Findings: A total of 398,881 offspring were included in this study. Of these, 3.9% had at least one parent with AUD. Parental AUD was significantly associated with the development of SUD in offspring. Having one parent with AUD was linked to a 1.44-fold increased risk (95% CL, 1.29-1.61), while having two parents with AUD was linked to a 2.29-fold increased risk (95% Cl, 1.64-3.20). No significant differences were found in relation to either parental or offspring gender.Conclusions: Exposure to parental AUD is linked to an increased risk of offspring developing SUD. This risk is additive for offspring exposed to double parental AUD. The findings have important implications for clinical assessment and intervention strategies, as well as the management of offspring exposed to parental AUD. (C) 2016 Elsevier Ltd. All rights reserved.