A new challenge for America: the National Cholesterol Education Program.
A new challenge for America: the National Cholesterol Education Program.
复制标题
美国面临的新挑战：国家胆固醇教育计划。
DOI：
10.1161/01.cir.73.5.855
复制
发表时间：
1986
期刊：
影响因子：
37.8
通讯作者：
C. Lenfant
中科院分区：
文献类型：
--
作者：
C. Lenfant
迅速传播到实践中。因此，NHBPEP是研究所对大量科学证据做出的合乎逻辑的反应，这些证据清楚地表明了与高血压相关的严重不良健康后果以及特定疗法在减轻这些后果方面的有效性。NHLBI再次面临着类似的丰富的科学证据，这一次与血液胆固醇升高有关，它的回应将再次包括一项国家教育计划。1985年11月15日，NHLBI启动了一项全国胆固醇教育计划(NCEP)。多年来，越来越多的流行病学证据表明，血液胆固醇水平升高是冠心病的重要危险因素。然而，直到去年，还没有强有力的临床证据表明，通过降低血液胆固醇水平的干预可以降低心血管风险。在缺乏临床证据的情况下，NHLBI认为没有足够的科学理由来协调全国范围内的胆固醇教育工作。然后，1984年1月，NHLBI赞助的冠状动脉初级预防试验(CPPT)的结果公布。试验结果表明，通过使用目前可用的降胆固醇药物和修改饮食，高胆固醇血症中年男性首次发作冠心病的风险可以大幅降低。宣布这一消息后，NHLBI立即开始制定计划，以确保尽可能广泛地传播CPPT结果。包括在
are rapidly disseminated into practice. The NHBPEP was, therefore, a logical Institute response to the wealth of scientific evidence that clearly demonstrated the serious adverse health consequences associated with elevated blood pressure and the effectiveness of specific therapies in mitigating those consequences. The NHLBI is once again faced with a similar wealth of scientific evidence, this time relating to elevated blood cholesterol, and once again its response will include a national education program. On November 15, 1985, the NHLBI initiated a National Cholesterol Education Program (NCEP). Epidemiologic evidence implicating elevated blood cholesterol levels as an important risk factor for coronary heart disease has been accumulating for years. However, until last year there was no strong clinical evidence that cardiovascular risk could be lowered by interventions that lower blood cholesterol levels. Without the missing clinical evidence, the NHLBI believed that there was insufficient scientific justification for a concerted national cholesterol education effort. Then, in January 1984, the results of the NHLBIsponsored Coronary Primary Prevention Trial (CPPT) were announced. The trial results demonstrated that the risk of initial episodes of coronary heart disease could be substantially reduced in hypercholesterolemic middle-aged men through the use of currently available cholesterol-lowering agents and dietary modifications. Immediately after the announcement, the NHLBI began to develop plans to ensure the widest possible dissemination of the CPPT results. Included in the