The role of tumor immune microenvironment in chordoma: promising immunotherapy strategies.
The role of tumor immune microenvironment in chordoma: promising immunotherapy strategies.
复制标题
肿瘤免疫微环境在脉络膜炎中的作用：有前景的免疫治疗策略。
DOI：
10.3389/fimmu.2023.1257254
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发表时间：
2023
影响因子：
7.3
通讯作者：
Tang, Xiaodong
中科院分区：
文献类型：
--
作者：
Xu, Jiuhui;Shi, Qianyu;Wang, Boyang;Ji, Tao;Guo, Wei;Ren, Tingting;Tang, Xiaodong
软骨瘤是一种罕见的恶性骨肿瘤，治疗选择有限，对常规化疗和放疗具有抗性，靶向治疗也显示出疗效甚微。其发生发展机制的研究长期滞后，导致临床上缺乏有效的治疗靶点和有效的治疗药物。近年来，肿瘤免疫微环境在驱动肿瘤生长中的作用已成为肿瘤研究领域的热点和挑战性课题。免疫疗法在治疗各种肿瘤方面已显示出良好的效果。然而，对脉络膜免疫微环境的研究还处于起步阶段。在这篇综述中，我们的目的是提出一个全面的揭示以前的探索脉络膜免疫微环境，并提出有前途的免疫治疗策略的基础上，这些特点的脉络膜。
Chordoma is a rare malignant bone tumor with limited therapeutic options, which is resistant to conventional chemotherapy and radiotherapy, and targeted therapy is also shown with little efficacy. The long-standing delay in researching its mechanisms of occurrence and development has resulted in the dilemma of no effective treatment targets and no available drugs in clinical practice. In recent years, the role of the tumor immune microenvironment in driving tumor growth has become a hot and challenging topic in the field of cancer research. Immunotherapy has shown promising results in the treatment of various tumors. However, the study of the immune microenvironment of chordoma is still in its infancy. In this review, we aim to present a comprehensive reveal of previous exploration on the chordoma immune microenvironment and propose promising immunotherapy strategies for chordoma based on these characteristics.
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影响因子：
10.9
作者：
DeMaria PJ;Lee-Wisdom K;Donahue RN;Madan RA;Karzai F;Schwab A;Palena C;Jochems C;Floudas C;Strauss J;Marté JL;Redman JM;Dombi E;Widemann B;Korchin B;Adams T;Pico-Navarro C;Heery C;Schlom J;Gulley JL;Bilusic M
通讯作者：
Bilusic M
影响因子：
7.2
作者：
de Gramont A;Faivre S;Raymond E
通讯作者：
Raymond E
影响因子：
7.3
作者：
Corgnac S;Boutet M;Kfoury M;Naltet C;Mami-Chouaib F
通讯作者：
Mami-Chouaib F
影响因子：
5.8
作者：
Collins, Julie M.;Donahue, Renee N.;Bilusic, Maruo
通讯作者：
Bilusic, Maruo
影响因子：
7.7
作者：
Barrett RL;Puré E
通讯作者：
Puré E