Handheld cellular telephone use and risk of brain cancer
Handheld cellular telephone use and risk of brain cancer
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DOI：
10.1001/jama.284.23.3001
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发表时间：
2000-12-20
影响因子：
120.7
通讯作者：
Wynder, EL
中科院分区：
文献类型：
--
作者：
Muscat, JE;Malkin, MC;Wynder, EL
背景使用手机可能对健康产生影响的数据相对匮乏。目的验证使用手持手机与患脑癌风险相关的假设。设计并设置病例对照研究，于1994至1998年间在美国5个学术医学中心使用结构化问卷。研究对象为469名年龄在18-80岁之间的原发性脑癌患者和422名匹配的对照组。主要结果与使用手持手机相比，每月使用手机的小时数和使用年限。结果患者的月平均使用小时数为2.5小时，对照组为2.2小时。与从不使用手持移动电话的患者相比，过去或现在经常使用手机的多变量优势比(OR)为0.85(95%可信区间[CI]，0.6-1.2)。不频繁使用(10.1h/mo)的OR值为0.7(95%CI，0.3~1.4)。病例的平均使用时间为2.8年，对照组为2.7年；根据使用时间的长短，未发现与脑癌有关(P=.54)，在使用手机的病例中，脑肿瘤发生在使用手机的同侧(26例比15例；P=0.06)，但在颞叶癌病例中，肿瘤发生在对侧的比例高于同侧(9例比5例；P=.33)。除少见的神经上皮瘤外，所有脑癌的OR值均小于1.0(OR，2.1；95%CI，0.9~4.7)。结论手持手机的使用与脑癌的发病风险无关，但对于诱导期较长的肿瘤，特别是具有神经元特征的生长缓慢的肿瘤，仍需进一步研究。
Context A relative paucity of data exist on the possible health effects of using cellular telephones.Objective To test the hypothesis that using handheld cellular telephones is related to the risk of primary brain cancer.Design and Setting Case-control study conducted in 5 US academic medical centers between 1994 and 1998 using a structured questionnaire.Patients A total of 469 men and women aged 18 to 80 years with primary brain cancer and 422 matched controls without brain cancer.Main Outcome Measure Risk of brain cancer compared by use of handheld cellular telephones, in hours per month and years of use.Results The median monthly hours of use were 2.5 for cases and 2.2 for controls. Compared with patients who never used handheld cellular telephones, the multivariate odds ratio (OR) associated with regular past or current use was 0.85 (95% confidence interval [CI], 0.6-1.2). The OR for infrequent users (10.1 h/mo) was 0.7 (95% CI, 0.3-1.4). The mean duration of use was 2.8 years for cases and 2.7 years for controls; no association with brain cancer was observed according to duration of use (P=.54), In cases, cerebral tumors occurred more frequently on the same side of the head where cellular telephones had been used (26 vs 15 cases; P=.06), but in the cases with temporal lobe cancer a greater proportion of tumors occurred in the contralateral than ipsilateral side (9 vs 5 cases; P=.33). The OR was less than 1.0 for all histologic categories of brain cancer except for uncommon neuroepitheliomatous cancers (OR, 2.1; 95% CI, 0.9-4.7).Conclusions Our data suggest that use of handheld cellular telephones is not associated with risk of brain cancer, but further studies are needed to account for longer induction periods, especially for slow-growing tumors with neuronal features.