Effects of 14 days of spaceflight and nine days of recovery on cell body size and succinate dehydrogenase activity of rat dorsal root ganglion neurons
Effects of 14 days of spaceflight and nine days of recovery on cell body size and succinate dehydrogenase activity of rat dorsal root ganglion neurons
复制标题
DOI：
10.1016/s0306-4522(97)00097-3
复制
发表时间：
1997-11-01
期刊：
影响因子：
3.3
通讯作者：
Edgerton, VR
中科院分区：
文献类型：
--
作者：
Ishihara, A;Ohira, Y;Edgerton, VR
测定了航天14天和恢复9天后大鼠背根神经节神经元L-5的横截面积和琥珀酸脱氢酶活性。无论是航天飞行组还是航天加回收组，横截面面积的平均值和分布都与年龄匹配的地面对照相似。航天大鼠的琥珀酸脱氢酶平均活性显著低于年龄匹配的对照组大鼠，而年龄匹配的对照组和航天+康复大鼠的平均琥珀酸脱氢酶活性相似。航天和航天+恢复组横截面积在1000-2000微米(2)之间的神经元琥珀酸脱氢酶平均活性均低于相应的对照组(在7-10%之间)。航天后即刻具有较大横截面积的感觉神经元亚群的氧化能力下降，并在恢复到1g后持续抑制9d，表明0g环境导致本体感觉功能发生显著变化。(C)1997年IBRO。爱思唯尔科学有限公司出版。
The cross-sectional areas and succinate dehydrogenase activities of L-5 dorsal root ganglion neurons in rats were determined after 14 days of spaceflight and after nine days of recovery. The mean and distribution of the cross-sectional areas were similar to age-matched, ground-based controls for both the spaceflight and for the spaceflight plus recovery groups. The mean succinate dehydrogenase activity was significantly lower in spaceflight compared to aged-matched control rats, whereas the mean succinate dehydrogenase activity was similar in age-matched control and spaceflight plus recovery rats. The mean succinate dehydrogenase activity of neurons with cross-sectional areas between 1000 and 2000 mu m(2) was lower (between 7 and 10%) in both the spaceflight and the spaceflight plus recovery groups compared to the appropriate control groups.The reduction in the oxidative capacity of a subpopulation of sensory neurons having relatively large cross-sectional areas immediately following spaceflight and the sustained depression for nine days after returning to 1 g suggest that the 0 g environment induced significant alterations in proprioceptive function. (C) 1997 IBRO. Published by Elsevier Science Ltd.