MUSCLE DEFICIENCY AND NEONATAL DEATH IN MICE WITH A TARGETED MUTATION IN THE MYOGENIN GENE
MUSCLE DEFICIENCY AND NEONATAL DEATH IN MICE WITH A TARGETED MUTATION IN THE MYOGENIN GENE
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DOI：
10.1038/364501a0
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发表时间：
1993-08-05
期刊：
影响因子：
64.8
通讯作者：
KLEIN, WH
中科院分区：
文献类型：
--
作者：
HASTY, P;BRADLEY, A;KLEIN, WH
肌原素是一种肌肉特异性转录因子，可以在组织培养中诱导多种细胞类型的肌生成。为了测试肌原素在体内的作用，产生了肌原素基因靶向突变的小鼠纯合子。这些小鼠在胎儿发育中存活下来，但在出生后立即死亡，所有骨骼肌都严重减少。肌原素突变小鼠不同于携带相关肌生成因子Myf5和MyoD基因突变的小鼠，后者没有肌肉缺陷。因此，肌原素对功能性骨骼肌的发育至关重要。
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.