Acute Liver Dysfunction among Workers Exposed to 2,2‐Dichloro‐1,1,1‐trifluoroethane (HCFC‐123): A Case Report
Acute Liver Dysfunction among Workers Exposed to 2,2‐Dichloro‐1,1,1‐trifluoroethane (HCFC‐123): A Case Report
复制标题
接触 2,2-二氯-1,1,1-三氟乙烷 (HCFC-123) 的工人发生急性肝功能障碍：病例报告
DOI：
10.1539/joh.40.169
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发表时间：
1998
影响因子：
3
通讯作者：
K. Omae
中科院分区：
文献类型：
--
作者：
Toru Takebayashi;I. Kabe;Yu'ichi Endo;S. Tanaka;H. Miyauchi;Kazuko Nozi;Ken Takahashi;K. Omae
2，2-二氯-1，1，1-三氟乙烷(HCFC-123；CAS No.306-83-2)是一种沸点为27.6°C(1托)、臭氧消耗潜力为0.02的无色轻醚气味液体，是作为制冷剂的著名臭氧消耗物质三氯氟甲烷(CFC-11)的替代品，根据日本氟碳制造商协会的调查数据，1996年日本的年出货量为500吨。1997年8月，建立了一个生产小容器(体积约15毫升)的工作场所，其中包括作为制冷剂的HCFC123。制造过程包括准备过程、制冷剂封闭过程，在该过程中将HCFC-123液体注入容器，检查其泄漏，并焊接容器，以及检查过程。在9月中旬制冷剂封存过程开始时，HCFC-123的使用量有所增加。本报告描述了14名在加工过程中反复接触HCFC123的工人发生肝功能障碍的事件，以及他们的健康监测结果。
2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123; CAS No. 306-83-2), a colorless light-ether-odor liquid with a boiling point of 27.6°C (at 1 Torr) and an ozone depletion potential of 0.02, is a substitute for a well-known ozone depleting substance trichlorofluoromethane (CFC-11) as a refrigerant, and 500 tons a year was shipped in Japan in 1996 according to the statistics surveyed by the Japan Fluorocarbon Manufacturers Association. In August, 1997, a workplace was set up to produce a small container (ca. 15 ml in volume) including HCFC123 as a refrigerant. The manufacturing process consisted of a preparation process, a refrigerant enclosure process in which HCFC-123 liquid is injected into a container, its leakage is checked, and the container is welded, and an inspection process. Use of HCFC-123 increased in mid-September when the refrigerant enclosure process started. This report describes the incident of liver dysfunction among 14 workers repeatedly exposed to HCFC123 in the processes, and the results of their health surveillance.