Uveal malignant melanoma associated with ocular and oculodermal melanocytosis.
Uveal malignant melanoma associated with ocular and oculodermal melanocytosis.
复制标题
葡萄膜恶性黑色素瘤与眼部和眼真皮黑色素细胞增多症相关。
DOI：
10.1016/s0161-6420(82)34694-1
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发表时间：
1982
期刊：
影响因子：
13.7
通讯作者：
Lavin,PT
中科院分区：
文献类型：
--
作者：
Gonder,JR;Shields,JA;Albert,DM;Augsburger,JJ;Lavin,PT
在1，250名患有葡萄膜恶性黑色素瘤的白人患者中，确定了17名患有眼或眼皮肤黑色素细胞增多症的患者。这17例患者的葡萄膜黑色素瘤在大小、细胞类型和转移倾向方面与报告的无眼部或眼皮肤黑色素细胞增多症的人群相似。17例患者的临床和组织病理学研究表明，所有受影响的眼睛都有巩膜和脉络膜黑色素细胞增多症，其他眼和眼周组织（巩膜，虹膜，结膜，角结构和视盘）的参与较少。葡萄膜恶性黑色素瘤是目前在每一个这些案件涉及的眼睛与黑色素细胞增多症。此外，黑色素瘤起源于每只眼睛的葡萄膜黑色素细胞增多区，并伴有扇形受累。这些数据的统计分析支持了葡萄膜恶性黑色素瘤在患有眼或眼皮肤黑色素细胞增多症的白色人中的发病率高于那些没有这些条件的人的论点。
Seventeen patients with ocular or oculodermal melanocytosis were identified among 1,250 Caucasian patients with uveal malignant melanoma. The uveal melanomas in these seventeen patients were similar in size, cell type, and tendency to metastasize to those occurring in reported populations without ocular or oculodermal melanocytosis. Clinical and histopathologic study of these 17 cases indicated that all of the affected eyes had episcleral and choroidal melanocytosis and that other ocular and periocular tissues (sclera, iris, conjunctiva, angle structures, and optic disc) were involved less commonly. The uveal malignant melanoma that was present in each of these cases involved the eye with melanocytosis. Furthermore, the melanoma arose from the zone of uveal melanocytosis in every eye with sectoral involvement. Statistical analysis of these data supports the contention that uveal malignant melanoma has a higher incidence in white persons with ocular or oculodermal melanocytosis than in those without these conditions.