Cyclophilin A: a key player for etiological agent infection.
Cyclophilin A: a key player for etiological agent infection.
复制标题
亲环蛋白 A：病原体感染的关键因素
DOI：
10.1007/s00253-021-11115-2
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发表时间：
2021-03
影响因子：
5
通讯作者：
Zeng Y
中科院分区：
文献类型：
--
作者：
Liao Y;Luo D;Peng K;Zeng Y
摘要亲环蛋白A （cyclophilin A, CypA）是人类已知的18种亲环蛋白中表达量最高的同工酶，是亲免疫蛋白家族的重要成员。除了作为环孢素A的细胞内受体外，CypA在微生物感染、心血管疾病、肝脏疾病、肾脏疾病、神经退行性疾病、癌症、类风湿关节炎、牙周炎、败血症、哮喘和衰老中起着至关重要的作用。本文综述了CypA在病原感染中的关键作用，主要表现为根据宿主细胞类型和病毒种类促进或抑制病毒复制。CypA可以与病毒蛋白相互作用，从而调节病毒的复制周期。CypA通过调节宿主肌动蛋白骨架的形成或细菌毒素的膜易位参与致病性细菌感染，或在感染过程中作为m的细胞受体介导生殖支原体的粘附。支原体。CypA还在感染或某些寄生虫的生命周期或宿主免疫调节中起关键作用。此外，我们总结了目前对CypA抑制剂作为宿主靶向抗病毒药物的理解，从而为多种病毒感染的治疗开辟了一条途径，因为它们具有广泛的抗病毒作用和有效预防耐药性的能力。因此，CypA的抗病毒作用有可能促进CypA抑制剂作为宿主靶向药物治疗与CypA有关的病原感染和人类疾病。•CypA参与多种病毒、致病菌、支原体和寄生虫的复制和感染。•CypA抑制剂在抑制病毒、细菌和支原体感染方面具有很强的作用。
AbstractCyclophilin A (CypA), a key member of the immunophilin family, is the most abundantly expressed isozyme of the 18 known human cyclophilins. Besides acting as an intracellular receptor for cyclosporine A, CypA plays a vital role in microorganismal infections, cardiovascular diseases, liver diseases, kidney diseases, neurodegeneration, cancer, rheumatoid arthritis, periodontitis, sepsis, asthma, and aging. This review focuses on the pivotal roles of CypA in the infection of etiological agents, which manifests mainly in promoting or inhibiting viral replication based on the host cell type and viral species. CypA can interact with viral proteins and thus regulate the replication cycle of the virus. CypA is involved in pathogenic bacterial infections by regulating the formation of host actin skeleton or membrane translocation of bacterial toxins, or mediated the adhesion ofMycoplasma genitaliumduring the infection processes by acting as a cellular receptor ofM. genitalium. CypA also plays a critical role in infection or the life cycle of certain parasites or host immune regulation. Moreover, we summarized the current understanding of CypA inhibitors acting as host-targeting antiviral agents, thus opening an avenue for the treatment of multiple viral infections due to their broad antiviral effects and ability to effectively prevent drug resistance. Therefore, the antiviral effect of CypA has the potential to promote CypA inhibitors as host-targeting drugs to CypA-involved etiological agent infections and human diseases.Key points•CypA is involved in the replication and infection of several viruses, pathogenic bacteria, mycoplasma, and parasites.•CypA inhibitors are in a strong position to inhibit the infection of viruses, bacterial, and mycoplasma.
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影响因子：
4.8
作者：
Dutta, M;Delhi, P;Datta, AK
通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1002/ar.23957
发表时间：
2018-12-01
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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