Left Ventricular Noncompaction Is Associated with Valvular Regurgitation and a Variety of Arrhythmias.
Left Ventricular Noncompaction Is Associated with Valvular Regurgitation and a Variety of Arrhythmias.
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DOI：
10.3390/jcdd9020049
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发表时间：
2022-02-02
影响因子：
2.4
通讯作者：
Wu M
中科院分区：
文献类型：
--
作者：
Li Q;Miao L;Xia L;Abdelnasser HY;Zhang F;Lu Y;Nusrat A;Tabassum M;Li J;Wu M
左心室致密化不全（LVNC）是一种心肌病，其解剖学特征为突出的心室小梁和深小梁间隐窝。与 LVNC 相关的死亡率范围为 5% 至 47%。尽管 LVNC 被全球认可为临床实体已过去数十年，但其病因尚未完全了解。此外，关键问题，即 LVNC 是否代表后天性病理学或先天性起源，以及 LVNC 患者收缩功能降低是否是致密化不全的原因或后果，仍有待解决。在本研究中，为了回答其中一些问题，我们分析了 LVNC 患者的临床特征。在 9582 名接受异常心脏功能筛查的受试者中，45 名表现出 LVNC 特征，1 名出现右心室致密化不全 (RVNC)。我们发现 40 名患者表现出瓣膜关闭不全，39 名患者表现出收缩期收缩减少，46 名患者中的 46 名患者出现不同形式的心律失常，这些心律失常不限于由非致密性心肌引起。对 LVNC 患者的回顾性检查揭示了一些新的发现：LVNC 与大多数患者的反流和所有患者的心律失常有关。小梁层与致密层的厚度比与缩短分数负相关，并且 LVNC 可能导致收缩性降低。这项研究增加了支持 LVNC 的先天性起源的证据，这可能有利于 LVNC 患者的诊断和随后的表征。
Left ventricular noncompaction (LVNC) is a type of cardiomyopathy characterized anatomically by prominent ventricular trabeculation and deep intertrabecular recesses. The mortality associated with LVNC ranges from 5% to 47%. The etiology of LVNC is yet to be fully understood, although decades have passed since its recognition as a clinical entity globally. Furthermore, critical questions, i.e., whether LVNC represents an acquired pathology or has a congenital origin and whether the reduced contractile function in LVNC patients is a cause or consequence of noncompaction, remain to be addressed. In this study, to answer some of these questions, we analyzed the clinical features of LVNC patients. Out of 9582 subjects screened for abnormal cardiac functions, 45 exhibit the characteristics of LVNC, and 1 presents right ventricular noncompaction (RVNC). We found that 40 patients show valvular regurgitation, 39 manifest reduced systolic contractions, and 46 out of the 46 present different forms of arrhythmias that are not restricted to be caused by the noncompact myocardium. This retrospective examination of LVNC patients reveals some novel findings: LVNC is associated with regurgitation in most patients and arrhythmias in all patients. The thickness ratio of the trabecular layer to compact layer negatively correlates with fractional shortening, and reduced contractility might result from LVNC. This study adds evidence to support a congenital origin of LVNC that might benefit the diagnosis and subsequent characterization of LVNC patients.
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影响因子：
4.5
作者：
Choquet C;Nguyen THM;Sicard P;Buttigieg E;Tran TT;Kober F;Varlet I;Sturny R;Costa MW;Harvey RP;Nguyen C;Rihet P;Richard S;Bernard M;Kelly RG;Lalevée N;Miquerol L
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通讯作者：
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作者：
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