Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior
Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior
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DOI：
10.1007/s00213-006-0398-z
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发表时间：
2006-04
影响因子：
3.4
通讯作者：
M. Nomura;I. Kusumi;M. Kaneko;T. Masui;M. Daiguji;T. Ueno;T. Koyama;Y. Nomura
中科院分区：
文献类型：
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作者：
M. Nomura;I. Kusumi;M. Kaneko;T. Masui;M. Daiguji;T. Ueno;T. Koyama;Y. Nomura
基本原理和目的 冲动行为的发生被认为是由于血清素能 5-HT 神经传递功能障碍所致。通过自我报告测量进行评估后，5-HT2A 受体基因启动子的多态性被认为是冲动行为的基础；然而，这个假设并不令人信服。在本研究中，我们通过评估正常志愿者的行为任务（进行/不进行任务）来检查该 5-HT2A 受体基因多态性是否与冲动攻击有关。 材料和方法使用来自 71 名志愿者的淋巴细胞，通过聚合酶链反应分析 5-HT2A 受体基因启动子的多态性。冲动性被定义为在执行/不执行任务期间犯下的犯错次数（犯错次数越多，表明抑制行为的难度越大）。 结果 具有 5-HT2A 受体基因 A-1438A 等位基因的组（A-1438A 组）中的受试者在执行/不执行任务的惩罚-奖励条件下犯下的犯错比 G-1438G 组中的受试者更多。结论这些结果表明5-HT2A受体基因的A-1438A多态性可能与冲动行为有关。这是使用行为任务测量来评估的，可以直接揭示人类冲动行为的特征。
Rationale and objectiveImpulsive behavior has been suggested to occur due to a dysfunction of serotonergic 5-HT neurotransmission. After evaluation by a self-reporting measure, a polymorphism in the promoter of the 5-HT2Areceptor gene has been proposed to underlie the impulsive behavior; however, this hypothesis is not convincing. In this study, we examined whether this 5-HT2Areceptor gene polymorphism is involved in impulsive aggression by evaluating a behavioral task (go/no-go task) in normal volunteers.Materials and methodsThe polymorphism of the 5-HT2Areceptor gene promoter was analyzed by polymerase chain reaction using lymphocytes from 71 volunteers. Impulsivity was defined as the number of commission errors (responding when one should not) made during a go/no-go task (a larger number of commission errors indicates greater difficulty in inhibiting the behavior).ResultsThe subjects in the group with the A-1438A allele of the 5-HT2Areceptor gene (A-1438A group) made more commission errors under the punishment–reward condition in a go/no-go task than those in the G-1438G group.ConclusionsThese results suggest the possible involvement of the A-1438A polymorphism of the 5-HT2Areceptor gene in impulsive behavior; this was evaluated using a behavioral task measure that can directly reveal the traits of human impulsive behavior.