Polymer Films Composed of Surface‐Bound Nanofilaments with a High Aspect Ratio, Molecularly Imprinted with Small Molecules and Proteins
Polymer Films Composed of Surface‐Bound Nanofilaments with a High Aspect Ratio, Molecularly Imprinted with Small Molecules and Proteins
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DOI：
10.1002/adfm.200801222
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发表时间：
2009-04
影响因子：
19
通讯作者：
A. Linares;F. Vandevelde;J. Pantigny;A. Falcimaigne-Cordin;K. Haupt
中科院分区：
文献类型：
--
作者：
A. Linares;F. Vandevelde;J. Pantigny;A. Falcimaigne-Cordin;K. Haupt
近年来，结合两个或两个以上层次结构并表现出多种有用特征的分层纳米结构材料获得了相当大的兴趣。本文描述了在纳米孔模板表面上通过纳米成型制备具有高纵横比的表面结合纳米纤维丝的方法。同时，这些细丝携带着分子印迹的结合位点。染料荧光素和蛋白肌红蛋白被用作印迹的模型模板。荧光显微镜显示，表面表现出特异性结合。表面的润湿性能取决于纳米丝的尺寸和聚合物的性质。人们相信这些材料在生物传感器和生物芯片方面具有潜在的应用价值。
Hierarchically nanostructured materials that combine two or more levels of structuring and that exhibit a combination of useful features have gained considerable interest over recent years. Here, the generation of surface‐bound nanofilaments with a high aspect ratio by nanomolding on a nanoporous template surface is described. The filaments, at the same time, carry molecularly imprinted binding sites. The dye fluorescein and the protein myoglobin are used as model templates for imprinting. The surfaces exhibit specific binding as revealed by fluorescence microscopy. The wetting properties of the surfaces depend on the dimensions of the nanofilaments and on the nature of the polymer. It is believed that these materials can potentially be useful for applications in biosensors and biochips.