ENHANCED BRAIN PROTECTION DURING PASSIVE HYPERTHERMIA IN HUMANS
ENHANCED BRAIN PROTECTION DURING PASSIVE HYPERTHERMIA IN HUMANS
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DOI：
10.1007/bf00635367
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发表时间：
1987-01-01
影响因子：
3
通讯作者：
CABANAC, M
中科院分区：
文献类型：
--
作者：
BRINNEL, H;NAGASAKA, T;CABANAC, M
在动物和人类的热疗过程中，通过从头部皮肤到大脑的使者静脉途径选择性地冷却大脑已经有报道。大脑的热保护扩展了动物对高体温的耐受性，如果头部冷却，可能会增强人类的耐受性。为了量化扇脸能在多大程度上保护大脑，9名未麻醉的人类志愿者被置于尽可能接近被动治疗性热疗的环境条件下。扇脸维持鼓室温度0.57度。温度低于食道温度，舒适度提高。因此，在热应激或被动治疗性热疗期间，增强大脑生理冷却的外部头部冷却技术可用于保护人类大脑。
Selective brain cooling during hyperthermia by emissary venous pathways from the skin of the head to the brain has been reported both in animals and humans. Heat protection of the brain extends tolerance to high deep body temperature in animals, and may be enhanced in humans if the head is cooled. In order to quantify to what extent brain protection could be obtained by face fanning, 9 non-anesthetized human volunteers were placed in ambient conditions as close as possible to those of passive therapeutic hyperthermia. Face-fanning maintained tympanic temperature 0.57.degree. C lower than esophageal temperature, and improved comfort. External head cooling techniques enhancing physiological brain cooling can therefore be useful for the protection of the human brain during heat stress or passive therapeutic hyperthermia.