Systemic lupus erythematosus and antiphospholipid antibody syndrome associated Addison disease: A case report.
Systemic lupus erythematosus and antiphospholipid antibody syndrome associated Addison disease: A case report.
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DOI：
10.11817/j.issn.1672-7347.2021.200758
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发表时间：
2021-07-28
期刊：
影响因子：
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通讯作者：
Xie, Yanli
中科院分区：
文献类型：
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作者：
Li, Zhilan;Peng, Yi;Xie, Yanli
Addison病是罕见的，与系统性红斑狼疮和抗磷脂抗体综合征并存更是罕见。我们在此报告一位中年女性，在2012年诊断为左下肢深静脉血栓形成和系统性红斑狼疮后，出现恶心、呕吐、皮肤和粘膜色素沉着过度、低血压、低钠血症和肺部感染。患者经血皮质醇、促肾上腺皮质激素节律、抗磷脂抗体等检查，最终诊断为系统性红斑狼疮伴Addison病继发抗磷脂抗体综合征，经激素、抗感染、抗凝治疗后临床好转。随访中患者病情稳定。临床上应重视系统性红斑狼疮、抗磷脂抗体综合征等结缔组织病患者的肾上腺损害，警惕肾上腺危象的发生。
Addison disease is rare, and it is rarer to coexist with systemic lupus erythematosus and antiphospholipid antibody syndrome. We hereby reported a middle-aged female who presented with nausea, vomit, skin and mucosa hyperpigmentation, hypotension, hyponatremia, and pulmonary infection after diagnosis of deep venous thrombosis of the left lower extremity and systemic lupus erythematosus in 2012. The patient was finally diagnosed with antiphospholipid antibody syndrome secondary to systemic lupus erythematosus with Addison disease after the examination, such as blood cortisol, adrenocorticotropic hormone rhythm, and antiphospholipid antibody, who was improved clinically after hormone, anti-infective, and anticoagulant treatment. The patient's condition was stable in the follow-up. In clinic, we should pay attention to adrenal damage in patients with connective tissue diseases such as systemic lupus erythematosus and antiphospholipid antibody syndrome, and be alert to the occurrence of adrenal crisis.