Zona Incerta: A Role in Central Pain
Zona Incerta: A Role in Central Pain
复制标题
DOI：
10.1152/jn.00152.2009
复制
发表时间：
2009-07-01
影响因子：
2.5
通讯作者：
Keller, Asaf
中科院分区：
文献类型：
--
作者：
Masri, Radi;Quiton, Raimi L.;Keller, Asaf
Masri R，Quiton RL，Lucas JM，Murray PD，Thompson SM，Keller A.未定带：中枢性疼痛的一个作用。J Neurophysiol 102：181-191，2009.首次发表于2009年4月29日; doi：10.1152/jn.00152.2009。中枢性疼痛综合征（CPS）是一种使人衰弱的病症，影响大量具有CNS原发性病变或功能障碍的患者。尽管它的发现超过世纪前，病理生理过程的发展和维护CPS的了解甚少。最近，我们证明，活动在后丘脑（PO）是严格调节的抑制性输入，从银杉（ZI）。在这里，我们测试的假设，CPS是与异常的抑制性调节PO ZI。我们在脊髓损伤导致CPS的动物中记录了ZI和PO的单个单位。与我们的假设相一致，自发放电率和体感诱发反应的ZI神经元损伤的动物相比，假手术对照组。在PO，神经元记录损伤大鼠表现出显着更高的自发放电率和更大的反应施加到后爪和脸的有害和无害的刺激。这些变化与三叉神经脊束核的传入驱动增加或丘脑腹后区的变化无关。因此，CPS可能是由抑制性齿状核到后丘脑的抑制性输入引起的。
Masri R, Quiton RL, Lucas JM, Murray PD, Thompson SM, Keller A. Zona incerta: a role in central pain. J Neurophysiol 102: 181-191, 2009. First published April 29, 2009; doi: 10.1152/jn.00152.2009. Central pain syndrome (CPS) is a debilitating condition that affects a large number of patients with a primary lesion or dysfunction in the CNS. Despite its discovery over a century ago, the pathophysiological processes underlying the development and maintenance of CPS are poorly understood. We recently demonstrated that activity in the posterior thalamus (PO) is tightly regulated by inhibitory inputs from zona incerta (ZI). Here we test the hypothesis that CPS is associated with abnormal inhibitory regulation of PO by ZI. We recorded single units from ZI and PO in animals with CPS resulting from spinal cord lesions. Consistent with our hypothesis, the spontaneous firing rate and somatosensory evoked responses of ZI neurons were lower in lesioned animals compared with sham-operated controls. In PO, neurons recorded from lesioned rats exhibited significantly higher spontaneous firing rates and greater responses to noxious and innocuous stimuli applied to the hind-paw and to the face. These changes were not associated with increased afferent drive from the spinal trigeminal nucleus or changes in the ventroposterior thalamus. Thus CPS can result from suppressed inputs from the inhibitory nucleus zona incerta to the posterior thalamus.