Migratory Aortitis Associated with Granulocyte-colony-stimulating Factor
Migratory Aortitis Associated with Granulocyte-colony-stimulating Factor
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DOI：
10.2169/internalmedicine.4331-19
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发表时间：
2020-01-01
影响因子：
1.2
通讯作者：
Harigae, Hideo
中科院分区：
文献类型：
--
作者：
Shirai, Tsuyoshi;Komatsu, Hiroka;Harigae, Hideo
我们在此报告一位有胰脏癌病史的65岁女性，在接受粒细胞集落刺激因子（G-CSF）治疗后，发生移行性腹膜炎。她正在接受培非格司亭给药，并在主动脉弓周围发生了胸膜炎。虽然在两周内消退，但在重新开始培非格司亭给药后，她在降主动脉周围再次发生了胸膜炎，表现为游走性胸膜炎。我们还经历了另外3例G-CSF诱导的腹膜炎，也显示自发消退，表明未使用或短期使用免疫抑制剂。G-CSF引起的主动脉炎可表现为游走性动脉炎，因为动脉炎可迅速消退，炎症可在不同部位复发。
We herein report a case of migratory aortitis after the administration of granulocyte-colony-stimulating factor (G-CSF) to a 65-year-old woman with a history of pancreatic cancer. She was being administered pegfilgrastim and developed aortitis around the aortic arch. Although it resolved within two weeks, she again developed aortitis around the descending aorta, presenting as migratory aortitis, after pegfilgrastim was resumed. We further experienced three additional cases of G-CSF-induced aortitis that also showed spontaneous resolution, suggesting no or short-term use of immunosuppression. Aortitis due to G-CSF can present as migratory aortitis, since aortitis can quickly resolve and inflammation can recur at a different location.