Suppression of Herpes Simplex Virus Infections with Oral Lithium Carbonate—A Possible Antiviral Activity
Suppression of Herpes Simplex Virus Infections with Oral Lithium Carbonate—A Possible Antiviral Activity
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口服碳酸锂抑制单纯疱疹病毒感染——一种可能的抗病毒活性
DOI：
10.1002/j.1875-9114.1996.tb03035.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
M. Hooper
中科院分区：
文献类型：
--
作者：
J. Amsterdam;G. Maislin;M. Hooper
体外研究表明，锂盐通过干扰病毒DNA合成的机制对单纯疱疹病毒（HSV）复制具有抑制作用。此外，临床研究表明，口服碳酸锂和局部琥珀酸锂可以抑制人类生殖器HSV感染。我们在11名年龄28-65岁（平均值± SD，年龄38 ± 11岁）的健康受试者中进行了一项口服碳酸锂的随机、双盲、安慰剂对照试验，这些受试者在研究前一年至少有4次复发性HSV感染。6例患者完成了至少5个月的锂治疗，平均（± SD）平均每日锂剂量为437 ± 185 mg（范围，150- 900 mg），平均血清锂水平为0.56 ± 0.20 mmol/L。总体而言，锂治疗导致每月平均发作次数、每次发作的平均持续时间、每月感染总天数和最大症状严重程度一致降低。相比之下，安慰剂治疗导致四个严重程度指标中的三个增加。尽管由于样本量有限，治疗组之间的比较未达到统计学显著性，但锂治疗组所有HSV感染的每月总持续时间有明显的减少“趋势”（p = 0.08）。锂治疗耐受性良好，对肾或甲状腺功能无有害影响。这些观察结果支持锂抗病毒活性的先前观察结果，并表明口服锂可能是复发性HSV感染患者的安全预防剂。
In vitro studies have shown an inhibitory effect of lithium salts on herpes simplex virus (HSV) replication by mechanisms that interfere with viral DNA synthesis. Moreover, clinical studies have shown that oral lithium carbonate and topical lithium succinate can suppress genital HSV infections in humans. We conducted a randomized, double‐blind, placebo‐controlled trial of oral lithium carbonate in 11 healthy subjects age 28–65 years (mean ± SD age 38 ± 11 years) who had at least four recurrent HSV infections in the year preceding the study. Six patients completed at least 5 months of, lithium therapy at a mean (± SD) average daily lithium dose of 437 ± 185 mg (range, 150–900mg) and an average serum lithium level of 0.56 ± 0.20 mmol/L. Overall, lithium treatment resulted in a consistent reduction in the mean number of episodes/month, the average duration of each episode, the total number of infection days/month, and the maximum symptom severity. In contrast, treatment with placebo resulted in an increase in three out of the four severity measures. Although the comparisons between the treatment groups did not achieve statistical significance due to the limited sample size, there was a clear “trend” for a reduction in the total monthly duration of all HSV infections with lithium (p = 0.08). Lithium treatment was well tolerated and produced no deleterious effects on renal or thyroid function. These observations lend support to prior observations of an antiviral activity of lithium, and suggest the possibility that oral lithium may represent a safe prophylactic agent in patients with recurrent HSV infections.
DOI：
10.1016/s0006-291x(89)80112-3
发表时间：
1989-05-15
影响因子：
3.1
作者：
ZIAIE, Z;KEFALIDES, NA
通讯作者：
KEFALIDES, NA
锂诱发的肾脏疾病：一项前瞻性研究。
影响因子：
1.1
作者：
Jorkasky,DK;Amsterdam,JD;Oler,J;Braden,G;Alvis,R;Geheb,M;Cox,M
通讯作者：
Cox,M
氯化锂抑制受感染细胞 Protein-4 信使 RNA 的合成以及受单纯疱疹病毒 1 感染的内皮细胞中病毒脱氧核糖核酸聚合酶的合成。
DOI：
--
发表时间：
1994
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Ziaie,Z;Brinker,JM;Kefalides,NA
通讯作者：
Kefalides,NA