Drug refusal in schizophrenia and the wish to be crazy.
Drug refusal in schizophrenia and the wish to be crazy.
复制标题
精神分裂症的拒绝药物和疯狂的愿望。
作者：
T. Putten;E. Crumpton;C. Yale
在两组精神分裂症患者中研究了药物依从性的极端情况：29名习惯性药物拒绝者总是停止药物治疗，只是在几个月后再次入院，30名药物依从者患者习惯性地重新填充或注射抗精神病药物。拒绝服药者在停止服药后，经历了自我和谐的宏大精神病的复苏。相反，习惯性顺从者会出现代偿失调，表现为抑郁、焦虑、实际上缺乏宏大感和对疾病的某种意识等焦虑情绪。这些慢性精神分裂症患者拒绝服药不能归因于社会隔离、偏执诊断或继发性获益。判别函数分析表明，宏伟是两组之间最强大的判别变量。我们解释这些发现意味着，一些精神分裂症患者可能更喜欢一个自我和谐的宏伟的精神病相对药物诱导的正常。
The extremes of drug compliance were studied in two groups of schizophrenics: 29 habitual drug-refusers who invariably discontinued medication only to be readmitted several months later, and 30 drug-complier patients who habitually came in for their refills or injections of antipsychotic medication. The drug-refusers experienced the resurgence of an ego-syntonic grandiose psychosis after they discontinued medication. The habitual compliers, in contrast, developed decompensations characterized by such dysphoric affects as depression, anxiety, virtual absence of grandiosity, and some awareness of illness. The refusal of these chronic schizophrenics to take their medication could not be attributed to social isolation, paranoid diagnosis, or secondary gain. A discriminant function analysis showed grandiosity to be the most powerful discriminating variable between the two groups. We interpret these findings to mean that some schizophrenics may prefer an ego-syntonic grandiose psychosis to a relative drug-induced normality.