Effect of aqueous extract from Herniaria hirsuta L. on experimentally nephrolithiasic rats
Effect of aqueous extract from Herniaria hirsuta L. on experimentally nephrolithiasic rats
复制标题
DOI：
10.1016/j.jep.2004.06.028
复制
发表时间：
2004-11-01
影响因子：
5.4
通讯作者：
Ziyyat, A
中科院分区：
文献类型：
--
作者：
Atmani, F;Slimani, Y;Ziyyat, A
尽管医学治疗取得了相当大的进展，但目前还没有令人满意的药物来治疗肾结石。因此，本研究旨在寻找一种替代治疗方法，将毛疝用于肾结石大鼠，作为预防肾结石发生的药物。实验以正常大鼠和草酸钙（CaOx）肾结石大鼠为实验对象，为期3周。每周跟踪几个参数，包括饮水量、尿量和pH值、一些尿液化学物质和结晶尿。最后，在光镜下对肾脏进行分析。结果显示，肾结石大鼠的摄水量和尿量增加，但尿pH值在治疗第3周明显下降。尿草酸在未治疗大鼠的第二周显著增加，而在经疝气汤治疗的大鼠保持不变。然而，未经治疗的大鼠在第2周尿钙明显下降，而治疗大鼠保持不变。晶体尿定性分析显示，未经治疗的大鼠排出的是大的一水氧化钙晶体和少量的二水氧化钙晶体，而经治疗的大鼠排出的大多是小的二水氧化钙晶体。肾脏切片检查显示，与未治疗的大鼠相比，治疗大鼠的CaOx沉积有限。这些在体内获得的结果证实了毛疝的有益作用，并可能证明其作为预防草酸钙肾结石形成的药物的使用是合理的。(C) 2004年由爱思唯尔爱尔兰有限公司出版
Despite considerable progress in medical therapy, there is no satisfactory drug to treat kidney stones. Therefore, this current study is aimed to look for an alternative treatment by using Herniaria hirsuta on nephrolithiasic rats as a preventive agent against the development of kidney stones.The experiment was conducted in normal and calcium oxalate (CaOx) nephrolithiasic rats during 3 weeks. Several parameters were followed weekly including water intake, urinary volume and pH, some urinary chemistries, and crystalluria. At the end, kidneys were analyzed by light microscope.The results showed that water intake and urinary volume increased in nephrolithiasic rats, but their urinary pH decreased especially in the third week of treatment. Urinary oxalate increased significantly during the second week for untreated rats and remained constant in rats treated with Herniaria decoction. However, urinary calcium decreased significantly in week 2 in untreated rats and remained constant in treated rats. Qualitative analysis of crystalluria showed that untreated rats excreted large CaOx monohydrate and few dihydrate crystals while treated animals excreted mostly small CaOx dihydrate crystals. The examination of kidney sections revealed that CaOx deposition was limited in treated rats when compared to untreated ones.These results obtained in vivo confirmed the beneficial effect of Herniaria hirsuta and may justify its use as a preventive agent against the formation of calcium oxalate kidney stones. (C) 2004 Published by Elsevier Ireland Ltd.