Reversal of proteinuria by sorbinil, an aldose reductase inhibitor in spontaneously diabetic (BB) rats.
Reversal of proteinuria by sorbinil, an aldose reductase inhibitor in spontaneously diabetic (BB) rats.
复制标题
索宾尼尔（一种醛糖还原酶抑制剂）可逆转自发性糖尿病 (BB) 大鼠的蛋白尿。
DOI：
10.1159/000138367
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发表时间：
1988
期刊：
影响因子：
3.1
通讯作者：
Sciadini,M
中科院分区：
文献类型：
--
作者：
Beyer-Mears,A;Murray,FT;DelVal,M;Cruz,E;Sciadini,M
索比尼是一种醛糖还原酶抑制剂，用来阻止和/或逆转1型胰岛素依赖型BB自发性糖尿病大鼠的蛋白尿。在索比尼治疗前，糖尿病大鼠表现出高血糖和尿胆红素原、葡萄糖和蛋白质排泄增加。为了评估蛋白尿，24小时尿样分析了30,000至100,000道尔顿之间的总蛋白和个别成分。开始每日口服索比尼(20 mg/kg体重)，并在1、2和4个月后重新评估上述参数。结果表明，经过1个月的索比尼治疗后，所有糖尿病BB大鼠(n=12)的尿胆红素原均恢复正常，而尿蛋白排泄量减少(67%)或保持不变(16%)，尽管存在高血糖和糖尿。这些疗效在山梨醇治疗2个月后持续。4个月后，尽管存在高血糖和糖尿(n=12)，但蛋白质排泄恢复正常(6.56±3.34 mg/24小时)；与之形成鲜明对比的是，6只未治疗的大鼠继续出现蛋白尿(17.76±2.59 mg/d)。索比尼可减少白蛋白和一系列尿蛋白，范围在30,000至100,000道尔顿之间，这表明索比尼可能是一种治疗糖尿病肾病的方法，如蛋白尿减少所示。
Sorbinil, an aldose reductase inhibitor, was examined as a therapeutic agent to arrest and/or reverse proteinuria in ‘type 1’ insulin-dependent BB rats having spontaneous diabetes mellitus. Prior to sorbinil treatment, diabetic rats exhibited hyperglycemia and increased urinary excretion of urobilinogen, glucose and protein. To assess proteinuria, 24-hour urine samples were analyzed for both total protein and individual components between 30,000 and 100,000 daltons. Daily oral administration of sorbinil (20 mg/kg body weight) was initiated and the aforementioned parameters reevaluated after 1, 2 and 4 months. Results indicated that after 1 month of sorbinil treatment, urobilinogen was normalized in all diabetic BB rats (n = 12), whereas urinary protein excretion was either diminished (67%) or remained constant (16 %), despite persistence of hyperglycemia and glycosuria. These therapeutic effects were sustained after 2 months of sorbinil treatment. After 4 months, protein excretion was normalized (6.56 ± 3.34 mg/24h), despite persistence of hyperglycemia and glycosuria (n = 12); in marked contrast, 6 untreated rats continued to exhibit proteinuria (17.76 ± 2.59 mg/day). Sorbinil diminished albumin and a series of urinary proteins between 30,000 and 100,000 daltons, suggesting that sorbinil may represent a therapeutic approach to manage diabetic nephropathy as indicated by diminution of proteinuria.