Effects of diltiazem on pharmacokinetics of tacrolimus in relation to CYP3A5 genotype status in renal recipients: from retrospective to prospective
Effects of diltiazem on pharmacokinetics of tacrolimus in relation to CYP3A5 genotype status in renal recipients: from retrospective to prospective
复制标题
地尔硫卓对与肾脏受者 CYP3A5 基因型状态相关的他克莫司药代动力学的影响：从回顾性到前瞻性。
DOI：
10.1038/tpj.2010.42
复制
发表时间：
2011-08-01
影响因子：
2.8
通讯作者：
Huang, M.
中科院分区：
文献类型：
--
作者：
Li, J-L;Wang, X-D;Huang, M.
The impact of CYP3A5*3, a CYP3A5 nonexpresser genotype, on inhibitory effects of diltiazem on tacrolimus metabolism has not been assessed. In retrospective study, when coadministered with diltiazem, mean increments in dose-adjusted C-0D7, C-max and AUC(0-12h) for tacrolimus were larger in CYP3A5 expressers than in CYP3A5 nonexpressers (48.7 vs 3.7%, 31.7 vs 17.2% and 38.2 vs 18.5%, respectively). Subsequently, a prospective study was carried out, patients were randomized to algorithm-predicted dosing or standard dosing. For CYP3A5 expressers, an algorithm guided by CYP3A5 and diltiazem significantly reduced tacrolimus maintenance dosage (P = 0.009) and improved the accuracy of tacrolimus initial dose, resulting in reduction in out-of-range C-0 after initial dose (P = 0.002) and dose adjustments (P = 0.004). However, for CYP3A5 nonexpressers, primary end points were not achieved, and tacrolimus-sparing effect of diltiazem was not remarkable. Our study results show that CYP3A5 genotype-guided tacrolimus-diltiazem combination is a promising therapy in renal transplant recipients in the early postoperative stage. The Pharmacogenomics Journal (2011) 11, 300-306; doi:10.1038/tpj.2010.42; published online 1 June 2010
